- ►pnas.org CR Hancock, DH Han, M Chen, S Terada, T … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences It has been hypothesized that insulin resistance is mediated by a deficiency of
mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat diets
that cause insulin resistance have been reported to result in a decrease in ... Cited by 40 - Related articles - BL Direct - All 8 versions
EW Kraegen, GJ Cooney - Current Opinion in Lipidology, 2008 - journals.lww.com Introduction The hypothesis that insulin resistance is related to tri- glyceride
accumulation in muscle and liver dates back to studies of 15–20 years ago
showing that triglyceride accumulates in muscle of high fat-fed rats, ... Cited by 25 - Related articles - BL Direct - All 2 versions
- ►nih.gov KL Hoehn, C Hohnen-Behrens, A Cederberg, … - Cell metabolism, 2008 - Elsevier Insulin resistance is a common disorder caused by a wide variety of
physiological insults, some of which include poor diet, inflammation,
anti-inflammatory steroids, hyperinsulinemia, and dyslipidemia. The common ... Cited by 21 - Related articles - All 5 versions
FGS Toledo, EV Menshikova, K Azuma, Z … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— In obesity and type 2 diabetes, exercise combined with weight loss
increases skeletal muscle mitochondrial capacity. It remains unclear whether
mitochondrial capacity increases because of weight loss, improvements in ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org DG MacArthur, JT Seto, S Chan, KGR Quinlan … - Human Molecular Genetics, 2008 - Oxford Univ Press A common nonsense polymorphism (R577X) in the ACTN3 gene results in complete
deficiency of the fast skeletal muscle fiber protein -actinin-3 in an estimated
one billion humans worldwide. The XX null genotype is under-represented in ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►cnfindpark.cn JO Holloszy - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Patients with type 2 diabetes, insulin-resistant obese individuals, and
insulin-resistant offspring of patients with diabetes have 30% less mitochondria
in their skeletal muscles than age-matched healthy controls. It has been ... Cited by 19 - Related articles - All 6 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes.
The precise factors that lead to insulin resistance have not been elucidated
fully, but there is a strong association between insulin resistance and ... Cited by 13 - Related articles - All 5 versions
- ►eje.org HM De Feyter, NMA van den Broek, SFE Praet, … - European Journal of Endocrinology, 2008 - eje.org Objective: Several lines of evidence support a potential role of skeletal muscle
mitochondrial dysfunction in the pathogenesis of insulin resistance and/or type
2 diabetes. However, it remains to be established whether mitochondrial ... Cited by 10 - Related articles - BL Direct - All 5 versions
EJ Anderson, ME Lustig, KE Boyle, TL … - The Journal of Clinical Investigation, 2009 - pubmedcentral.nih.gov High dietary fat intake leads to insulin resistance in skeletal muscle, and this
represents a major risk factor for type 2 diabetes and cardiovascular disease.
Mitochondrial dysfunction and oxidative stress have been implicated in the ... Cited by 12 - Related articles - All 3 versions
J Hoeks, JJ Briedé, J de Vogel, G Schaart, … - FEBS letters, 2008 - Elsevier A high intake of dietary fat has been suggested to diminish mitochondrial
functioning in skeletal muscle, possibly attributing to muscular fat
accumulation. Here we show however, that an 8-week high-fat dietary ... Cited by 9 - Related articles - All 4 versions
