- ►ahajournals.org J Kim, Y Wei, JR Sowers - Circulation research, 2008 - Am Heart Assoc Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the cardiometabolic
syndrome, including hypertension and dyslipidemia, that collectively contribute to a substantial
risk for cardiovascular disease. Metabolic actions of insulin in classic insulin target tissues ... Cited by 49 - Related articles - All 6 versions
- ►physiology.org C Moro, S Bajpeyi, SR Smith - American Journal of Physiology- …, 2008 - Am Physiological Soc Increased intramyocellular triglyceride (IMTG) content is found in both insulin-sensitive
endurance-trained subjects and insulin-resistant obese/type 2 diabetic subjects. A high turnover
rate of the IMTG pool in athletes is proposed to reduce accumulation of lipotoxic ... Cited by 23 - Related articles - BL Direct - All 6 versions
FGS Toledo, EV Menshikova, K Azuma, Z Radiková, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— In obesity and type 2 diabetes, exercise combined with weight loss increases
skeletal muscle mitochondrial capacity. It remains unclear whether mitochondrial capacity increases
because of weight loss, improvements in insulin resistance, or physical training. In this ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►cnfindpark.cn JO Holloszy - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant offspring
of patients with diabetes have 30% less mitochondria in their skeletal muscles than age-matched
healthy controls. It has been hypothesized that this "deficiency" of mitochondria mediates ... Cited by 19 - Related articles - All 6 versions
- ►physiology.org TPJ Solomon, SN Sistrun, RK Krishnan, … - Journal of Applied …, 2008 - Am Physiological Soc Older, obese, and sedentary individuals are at high risk of developing diabetes and cardiovascular
disease. Exercise training improves metabolic anomalies associated with such diseases, but
the effects of caloric restriction in addition to exercise in such a high-risk group are not ... Cited by 13 - Related articles - BL Direct - All 7 versions
- ►nih.gov NP Hays, PR Galassetti, RH Coker - Pharmacology and Therapeutics, 2008 - Elsevier Common complications of type 2 diabetes (T2D) are eye, kidney and nerve diseases, as well
as an increased risk for the development of cardiovascular disease and cancer. The overwhelming
influence of these conditions contributes to a decreased quality of life and life span, as ... Cited by 12 - Related articles - All 4 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise factors
that lead to insulin resistance have not been elucidated fully, but there is a strong association
between insulin resistance and inappropriate lipid accumulation in insulin-target tissues. ... Cited by 13 - Related articles - All 5 versions
- ►physicaltherapyjournal.com LP Turcotte, JS Fisher - Physical Therapy, 2008 - physicaltherapyjournal.com The purpose of this review is to provide information about the role of exercise in the prevention
of skeletal muscle insulin resistance, that is, the inability of insulin to properly cause glucose
uptake into skeletal muscle. Insulin resistance is associated with high levels of stored ... Cited by 11 - Related articles - All 31 versions
M Blatnik, N Frizzell, SR Thorpe, JW Baynes - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—GAPDH was incubated with fumarate in PBS to assess
effects of fumarate on enzyme activity in vitro. Sites of 2SC formation were determined by analysis
of tryptic peptides by high-performance liquid chromatography–quadrupole/time-of-flight ... Cited by 6 - Related articles - BL Direct - All 5 versions
JWO Ballard, RG Melvin, JT Miller, SD Katewa - Journal of Anatomy - interscience.wiley.com The goal of this study is to test the role of mitochondria and of mitochondrial metabolism in determining
the processes that influence aging of female and male Drosophila. We observe that Drosophila
simulans females tended to have shorter lifespan, higher levels of hydrogen peroxide ... Cited by 7 - Related articles - BL Direct - All 3 versions
