- ►endojournals.org DL Eizirik, AK Cardozo, M Cnop - Endocrine Reviews, 2008 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis
of diabetes, contributing to pancreatic β-cell loss and insulin resistance. Components of the unfolded
protein response (UPR) play a dual role in β-cells, acting as beneficial regulators under ... Cited by 93 - Related articles - BL Direct - All 5 versions
P Pirot, AK Cardozo, DL Eizirik - Arquivos Brasileiros de Endocrinologia & …, 2008 - SciELO Brasil Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from chronic
and progressive destruction of pancreatic beta-cells by the immune system. The triggering of
autoimmunity against the beta-cells is probably caused by environmental agent(s) acting ... Cited by 10 - Related articles - Cached - All 4 versions
D Eizirik, F Moore, D Flamez, F Ortis - Biochemical Society …, 2008 - biochemsoctrans.org Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes
mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that
β-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory
component. The latest studies indicate that innate immunity and inflammatory mediators have
a much broader role in T1DM than initially assumed. Inflammation might contribute to ... Cited by 8 - Related articles - All 8 versions
E Lien, D Zipris - Current Molecular Medicine, 2009 - ingentaconnect.com 1 Department of Medicine, University of Massachusetts Medical School, Worcester, MA
01655, USA 2 Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University
of Colorado, Aurora, CO 80045, USA Abstract: Toll-like receptors (TLRs) and the innate ... Cited by 5 - Related articles - All 2 versions
D Zipris - Current Opinion in Endocrinology, Diabetes and …, 2008 - journals.lww.com Purpose of review: Over the last 2 decades, studies addressing mechanisms of type 1 diabetes
have focused primarily on the role of T lymphocytes in disease mechanisms. Recent
investigations, however, suggest that the innate immune system plays a key role in ... Cited by 4 - Related articles - All 3 versions
J Chen, Y Lu, CH Lee, R Li, EH Leiter, CE … - Free Radical Biology and …, 2008 - Elsevier ALR/Lt, a NOD-related mouse strain, was selected for resistance to alloxan free radical-mediated
diabetes (ALD). Despite extensive genomic identity with NOD (> 70%), ALR mice display strong
resistance to autoimmune type 1 diabetes (T1D) due to both an unusual elevation in ... Cited by 4 - Related articles - All 3 versions
N Lv, EK Kim, MY Song, HN Choi, WS Moon, SJ … - Experimental cell …, 2009 - Elsevier JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the
onset of diabetes in the NOD mouse model. However, the molecular mechanism by which
JANEX-1 protects pancreatic β-cells is unknown. In the current study, we investigated the ... Cited by 1 - Related articles - All 3 versions
