- ►nih.gov C de Luca, JM Olefsky - FEBS letters, 2008 - Elsevier Obesity-induced chronic inflammation is a key component in the pathogenesis of
insulin resistance and the Metabolic syndrome. In this review, we focus on the
interconnection between obesity, inflammation and insulin resistance. Pro- ... Cited by 70 - Related articles - All 11 versions
- ►diabetesjournals.org KJ Strissel, Z Stancheva, H Miyoshi, JW … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Frequency of adipocyte death in eAT increased from <0.1% at baseline
to 16% at week 12, coincident with increases in 1) depot weight; 2) AT
macrophages (ATMΦs) expressing F4/80 and CD11c; 3) mRNA for tumor necrosis ... Cited by 65 - Related articles - BL Direct - All 5 versions
H Tilg, AR Moschen - Molecular Medicine, 2008 - pubmedcentral.nih.gov Insulin resistance (IR) plays a key role in the pathophysiology of
obesity-related diseases such as type 2 diabetes and nonalcoholic fatty liver
disease. It has been demonstrated that IR is associated with a state of ... Cited by 61 - Related articles - BL Direct - All 6 versions
S Schenk, M Saberi, JM Olefsky - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor
in the etiology of a number of diseases, including type 2 diabetes. In this
review, we discuss potential mechanisms by which brief nutrient excess and ... Cited by 46 - Related articles - All 12 versions
- ►endojournals.org N Rasouli, PA Kern - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Context: Adipose tissue is increasingly recognized as an active endocrine organ
with many secretory products and part of the innate immune system. With obesity,
macrophages infiltrate adipose tissue, and numerous adipocytokines are ... Cited by 39 - Related articles - All 3 versions
H Tilg, A Moschen - Clinical Science, 2008 - submit.clinsci.org Abbreviations: AMPK, AMP-activated protein kinase; BAT, brown adipose tissue;
BMI, body mass index; CCL-2, CC chemokine ligand-2; CRP, C-reactive protein; DC,
dendritic cell; DSS, dextran sulphate sodium; HMW, high-molecular-weight ... Cited by 37 - Related articles - Cached - BL Direct - All 7 versions
M Zeyda, TM Stulnig - Immunology Letters, 2007 - Elsevier It is now broadly accepted that low-grade chronic inflammation associated with
obesity leads to the onset of insulin resistance and type 2 diabetes mellitus.
Obesity-associated inflammation is characterized by an increased abundance ... Cited by 34 - Related articles - All 3 versions
LK Heilbronn, LV Campbell - Current Pharmaceutical Design, 2008 - ingentaconnect.com Abstract: Obesity was first described as a low-grade inflammatory condition more
than a decade ago. However, it is only relatively re- cently that obese
individuals have been described with increased macrophage infiltration of ... Cited by 36 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org EA Kirk, ZK Sagawa, TO McDonald, KD O' … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We first established that the two strains were in the same genetic
background and that macrophage recruitment into inflamed peritoneum was markedly
reduced in the MCP-1–deficient animals. In striking contrast, independent ... Cited by 22 - Related articles - BL Direct - All 2 versions
M Furuhashi, R Fucho, CZ Görgün, G Tuncman … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Adipose tissue inflammation is a characteristic of obesity. However, the
mechanisms that regulate this inflammatory response and link adipose
inflammation to systemic metabolic consequences are not fully understood. ... Cited by 22 - Related articles - All 7 versions
