- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X … - American Journal of …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) but not rodent IAPP (rIAPP) forms toxic oligomers and amyloid fibrils in an ... Cited by 10 - Related articles - BL Direct - All 3 versions
T Ma, L Han, Y Gao, L Li, X Shang, W Hu, C Xue - Eur Surg Res, 2008 - content.karger.com Page 1. Fax +41 61 306 12 34 E-Mail karger@karger.ch www.karger.com Original Paper
Eur Surg Res 2008;41:219–225 DOI: 10.1159/000135631 The Endoplasmic Reticulum
Stress-Mediated Apoptosis Signal Pathway Is Involved in ... Cited by 3 - Related articles - All 4 versions
S Casas, A Novials, F Reimann, R Gomis, FM Gribble - Diabetologia, 2008 - Springer Abstract Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide
(hIAPP) fibril formation results in calcium influx across the plasma membrane of pancreatic beta
cells, and its association with apoptosis. Methods Cytoplasmic intracellular calcium ... Cited by 3 - Related articles - All 3 versions
S Wing - BMC biochemistry, 2008 - biomedcentral.com Type 2 diabetes is caused by defects in both insulin signaling and insulin secretion. Though
the role of the ubiquitin proteasome system (UPS) in the pathogenesis of type 2 diabetes remains
largely unexplored, the few examples present in the literature are interesting and suggest ... Cited by 2 - Related articles - Cached - All 6 versions
RL Hull, S Zraika, J Udayasankar, K Aston-Mourney, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Supraphysiological levels of the amyloi- dogenic peptide human islet
amyloid polypeptide have been associated with beta cell endoplasmic reticulum (ER) stress.
However, in human type 2 diabetes, levels of human IAPP are equivalent or decreased ... Cited by 1 - Related articles - All 2 versions
HL Zhao, Y Sui, J Guan, L He, XM Gu, HK Wong, L … - Translational Research, 2009 - Elsevier The amyloid hypothesis of type 2 diabetes mellitus postulates that elevated levels of normally
expressed monomeric proteins of human islet amyloid polypeptide (hIAPP) trigger oligomerization
that independently causes fibril formation and disease progression. The aim of this study ... Cited by 1 - Related articles - All 12 versions
Y Zhang, F Ranta, C Tang, E Shumilina, H Mahmud, M … - Apoptosis, 2009 - Springer Abstract Amyloid peptides interfere with survival of pancreatic beta-cells. In some cells apoptosis
is paralleled by ceramide-dependent alterations of ion channel activity. The purpose of the present
study was to elucidate the dependence of amyloid peptides Aß 1-42 and islet amyloid ... Related articles - All 2 versions
T Hartley, J Brumell, A Volchuk - American Journal of Physiology- …, 2009 - Am Physiological Soc Protein degradation in eukaryotic cells is mediated primarily by the ubiquitin-proteasome system
and autophagy. Turnover of protein aggregates and other cytoplasmic components, including
organelles, is another function attributed to autophagy. The ubiquitin-proteasome system ... Cited by 1 - Related articles - All 3 versions
J Altirriba, A Barbera, H Del Zotto, B Nadal, S … - BMC genomics, 2009 - biomedcentral.com Jordi Altirriba (jaltirri@clinic.ub.es) Albert Barbera (abarbera@clinic.ub.es) Hector Del Zotto
(hdelzotto@yahoo.com.ar) Belen Nadal (bnadal@ub.edu) Sandra Piquer
(spiquer@clinic.ub.es) Alex Sanchez-Pla (asanchez@ub.edu) Juan J Gagliardino ... Related articles - View as HTML - All 5 versions
