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Scholar Results 1 - 10 of about 17 citing Dezaki: Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induc.... (0.08 sec) 

Inhibitory effect of obestatin on glucose-induced insulin secretion in rats


AJ Ren, ZF Guo, YK Wang, LG Wang, WZ Wang … - Biochemical and Biophysical Research …, 2008 - Elsevier
Obestatin is a bioactive peptide encoded by the same gene that encodes ghrelin.
Our aim was to investigate the effect of obestatin on insulin secretion. We
evaluated the effects of obestatin on insulin secretion from rat islet ...
Cited by 9 - Related articles - All 4 versions

Introducing GOAT: a target for obesity and anti-diabetic drugs?

- cell.com
O Gualillo, F Lago, C Dieguez - Trends in Pharmacological Sciences, 2008 - Elsevier
The acyltransferase that catalyzes ghrelin octanoylation has recently been
identified as ghrelin O-acyltransferase (GOAT). GOAT belongs to a family of
membrane-bound O-acyltransferases (MBOATs). GOAT covalently links a medium ...
Cited by 6 - Related articles - All 4 versions

Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat …


EM Egido, R Hernández, J Marco, RA … - Regulatory Peptides, 2009 - Elsevier
Obestatin is a 23-amino acid peptide derived from preproghrelin, purified from
stomach extracts and detected in peripheral plasma. In contrast to ghrelin,
obestatin has been reported to inhibit appetite and gastric motility. ...
Cited by 2 - Related articles - All 3 versions

Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC …


BP Cummings, EK Digitale, KL Stanhope, JL … - … Journal of Physiology- Regulatory, Integrative and …, 2008 - Am Physiological Soc
The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM
animal models for the study of disease pathogenesis, prevention, and treatment.
The purpose of this project was to develop a rat model of T2DM that more ...
Cited by 1 - Related articles - All 3 versions

Novel factors as therapeutic targets to treat diabetes. Focus on leptin and ghrelin


R Gómez, F Lago, JJ Gómez-Reino, O … - Expert Opin. Ther. Targets, 2009 - informahealthcare.com
Background: Obesity is the major cause of type 2 diabetes. In the mid 1990s
interest in adipose tissue was revived by the discovery of leptin. The
association of obesity and diabetes emphasizes their shared ...
Related articles - All 6 versions

Ghrelin signalling in guinea-pig femoral artery smooth muscle cells


MI Mladenov, KL Hristov, DZ Dimitriova, R … - Acta Physiologica, 2008 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ...
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Cell–cell interactions in the endocrine pancreas


R Jain, E Lammert - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com
Cell–cell communication within any given tissue is an important aspect of
correct organ function. The islets of Langerhans forming the endocrine pancreas
are composed of α-, β-, δ-, ε- and PP-cells, and interactions between ...
Related articles - All 2 versions

Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super- …


KA Bennett, CJ Langmead, A Wise, G Milligan - Molecular Pharmacology, 2009 - ASPET
Some growth hormone secretagogues act as agonists at the ghrelin receptor and
have been described as "ago-allosteric" ligands because of an ability to also
modulate the maximum efficacy and potency of ghrelin (Holst et al., 2005 Go ...
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UNACYLATED GHRELIN AS THERAPEUTIC AGENT IN THE TREATMENT OF …


E Ghigo, R Granata, LAJ Van Der, 2008 - freepatentsonline.com
An isolated polypeptide comprising any amino acid fragment of unacylated ghrelin
or any analog thereof, wherein the polypeptide has an activity selected from the
group consisting of a) decreasing blood glucose levels; b) increasing ...
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[PDF] Cyclic AMP oscillations in insulin-secreting cells


J Sågetorp - uu.diva-portal.org
Dissertation presented at Uppsala University to be publicly examined in B21,
BMC, Husargatan 3, Uppsala, Saturday, March 21, 2009 at 09:15 for the degree of
Doctor of Philosophy (Faculty of Medicine). The examination will be ...
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