LR Brunham, JK Kruit, CB Verchere, MR … - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Type 2 diabetes (T2D) frequently occurs in the context of abnormalities of plasma
lipoproteins. However, a role for elevated levels of plasma cholesterol in the pathogenesis of
this disease is not well established. Recent evidence suggests that alterations of plasma ... Cited by 11 - Related articles - BL Direct - All 6 versions
MT Villarreal-Molina, MT Flores-Dorantes, O Arellano- … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—R230C/C230C genotypes were significantly more frequent in type 2 diabetic individuals
(24.6%) than in control subjects (11.4%) in the initial study group (OR 2.501; P = 0.001). After
stratifying by age at diagnosis, the association was significant only in the early-onset ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►endojournals.org F Xia, L Xie, A Mihic, X Gao, Y Chen, HY Gaisano, RG … - Endocrinology, 2008 - Endocrine Soc Insulin secretion from pancreatic β-cells is mediated by the opening of voltage-gated Ca 2+ channels
(Ca V ) and exocytosis of insulin dense core vesicles facilitated by the secretory soluble
N-ethylmaleimide-sensitive factor attachment protein receptor protein machinery. We ... Cited by 7 - Related articles - All 3 versions
DK Sanghera, SK Nath, L Ortega, M … - Annals of Human …, 2008 - interscience.wiley.com Recently, the transcription factor-7-like 2 (TCF7L2) gene has been identified as the most important
type 2 diabetes mellitus (T2DM) susceptibility gene. Common intronic polymorphisms in this
gene have been found to be strongly associated with T2DM susceptibility showing ... Cited by 6 - Related articles - All 4 versions
- ►umin.ac.jp [PDF] M Ishikawa, Y Iwasaki, S Yatoh, T Kato, S … - The Journal of Lipid …, 2008 - ASBMB To determine the role of cholesterol synthesis in pancreatic β-cells, a transgenic model of in vivo
activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in β-cells
(TgRIP-SREBP-2) was developed and analyzed. Expression of nuclear human SREBP-2 ... Cited by 2 - Related articles - All 7 versions
M Ishikawa, Y Iwasaki, S Yatoh, T Kato, S Kumadaki, N … - The Journal of Lipid … - ASBMB Page 1. 1 Overexpression of nuclear SREBP-2 in pancreatic β-cells results in cholesterol
accumulation leading to insulin secretion defects and diabetes :A new model for β-cell lipotoxicity
Mayumi Ishikawa1, Yuko Iwasaki1, Shigeru Yatoh1, Toyonori Kato1, Shin Kumadaki1, ... Related articles - All 2 versions
S Somanath, S Barg, C Marshall, CJ Silwood, MD … - … and Biophysical Research …, 2009 - Elsevier Diabetes is characterized by high blood glucose which eventually impairs the secretion of
insulin. Glucose directly affects cholesterol biosynthesis and may in turn affect cellular structures
that depend on the sterol, including lipid rafts that help organize the secretory apparatus. ... Related articles - All 2 versions
M Hao, JS Bogan - Journal of Biological Chemistry, 2009 - ASBMB * Correspondence to: Mingming Hao, Dept of Internal Medicine, Yale University, PO Box
208020, New Haven, CT 06520-8020, Phone (203) 785-3045, Fax (203) 785-6462, Email:
mingming.hao@yale.edu ... Membrane cholesterol modulates the ability of glucose to ... Related articles - All 3 versions
M Dou, AG Ma, QZ Wang, H Liang, Y Li, XM Yi, SC … - Nutrition Research, 2009 - Elsevier Although magnesium and vitamin E (VE) have differing effects on diabetes, both are
beneficial. We hypothesized that preventive supplementation of magnesium combined with VE
could improve the metabolism of lipids and blood viscosity more effectively than the use ... Related articles - All 8 versions
R Miccoli, C Bianchi, G Penno, S Del Prato - Future Lipidol., 2008 - Future Medicine The dyslipidemia of insulin resistance is characterized by elevated levels of triglycerides
(TGs), low HDL-cholesterol and small dense LDL particles. Many of these features are affected
by the reduction in insulin sensitivity, with a central role played by abnormalities in ... Related articles - All 8 versions
