SE Pinney, C MacMullen, S Becker, YW … - The Journal of …, 2008 - pubmedcentral.nih.gov Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating
mutations of the ATP-sensitive K + (K ATP ) channel in the pancreatic β cell. Though most
disease-causing mutations of the 2 genes encoding K ATP subunits, ABCC8 (SUR1) and ... Cited by 12 - Related articles - All 6 versions
B Schwappach - Molecular membrane biology, 2008 - informahealthcare.com Ionotropic neurotransmitter receptors and voltage-gated ion channels assemble from several
homologous and non-homologous subunits. Assembly of these multimeric membrane proteins
is a tightly controlled process subject to primary and secondary quality control ... Cited by 5 - Related articles - BL Direct - All 7 versions
YW Lin, JD Bushman, FF Yan, S Haidar, C … - Journal of Biological …, 2008 - ASBMB The inwardly rectifying potassium channel Kir6.2 is the pore-forming subunit of the ATP-sensitive
potassium (K ATP ) channel, which controls insulin secretion by coupling glucose metabolism
to membrane potential in β-cells. Loss of channel function because of mutations in Kir6.2 ... Cited by 4 - Related articles - All 4 versions
SE Flanagan, S Clauin, C Bellanné-Chantelot, P de … - Hum Mutat, 2009 - interscience.wiley.com The beta-cell ATP-sensitive potassium (K ATP ) channel is a key component of stimulus-secretion
coupling in the pancreatic beta-cell. The channel couples metabolism to membrane electrical
events bringing about insulin secretion. Given the critical role of this channel in glucose ... Cited by 5 - Related articles - All 3 versions
EB Pratt, FF Yan, JW Gay, CA Stanley, SL Shyng - Journal of Biological …, 2009 - ASBMB The β-cell ATP-sensitive potassium (K ATP ) channel composed of sulfonylurea receptor SUR1
and potassium channel Kir6.2 serves a key role in insulin secretion regulation by linking glucose
metabolism to cell excitability. Mutations in SUR1 or Kir6.2 that decrease channel function ... Cited by 1 - Related articles - All 3 versions
K Shimomura, SE Flanagan, B Zadek, M … - EMBO Molecular …, 2009 - interscience.wiley.com K ATP channels regulate insulin secretion from pancreatic -cells. Loss- and gain-of-function mutations
in the genes encoding the Kir6.2 and SUR1 subunits of this channel cause hyperinsulinism of
infancy and neonatal diabetes, respectively. We report two novel mutations in the gating ... Related articles
T Sandal, LB Laborie, K Brusgaard, SÅ Eide, … - Clinical …, 2009 - interscience.wiley.com Potassium channels in the plasma membrane of the pancreatic beta cells are critical in maintaining
glucose homeostasis by responding to ATP and coupling metabolic changes to insulin
secretion. These channels consist of subunits denoted the sulfonylurea receptor SUR1 ... Related articles - All 3 versions
E Hosy, JP Dupuis, M Vivaudou, M Vivaudou, J … - Journal of Biological …, 2009 - ASBMB Page 1. 1 IMPACT OF DISEASE-CAUSING SUR1 MUTATIONS ON THE KATP
CHANNEL SUBUNIT INTERFACE PROBED WITH A RHODAMINE PROTECTION
ASSAY Eric Hosy1, Julien P. Dupuis2, and Michel Vivaudou$ Institut ...