E Diamanti-Kandarakis - Endocrine, 2006 - Springer Polycystic ovary syndrome (PCOS) is the commonest endocrinopathy affecting women
of reproductive age, manifested with a variety of clinical signs, none of which
is pathognomonic. The association of insulin resistance and reproductive ... Cited by 20 - Related articles - BL Direct - All 5 versions
H Bugger - Clinical Science, 2008 - clinsci.org The metabolic syndrome represents a cluster of abnormalities, including obesity,
insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk
of developing cardiovascular diseases, such as coronary artery disease and ... Cited by 13 - Related articles - Cached - BL Direct - All 7 versions
S Palomba, A Falbo, F Zullo, F Orio Jr - Endocrine Reviews, 2009 - Endocrine Soc Metformin is an insulin sensitizer widely used for the treatment of patients
affected by type 2 diabetes mellitus. Because many women with polycystic ovary
syndrome (PCOS) are insulin resistant, metformin was introduced in clinical ... Cited by 13 - Related articles - All 6 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes.
The precise factors that lead to insulin resistance have not been elucidated
fully, but there is a strong association between insulin resistance and ... Cited by 13 - Related articles - All 5 versions
- ►jbc.org I Pagel-Langenickel, J Bao, JJ Joseph, DR … - Journal of Biological Chemistry, 2008 - ASBMB The pathophysiology underlying mitochondrial dysfunction in insulin-resistant
skeletal muscle is incompletely characterized. To further delineate this we
investigated the interaction between insulin signaling, mitochondrial ... Cited by 9 - Related articles - All 5 versions
- ►endojournals.org C Brons, CB Jensen, H Storgaard, A Alibegovic … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Objective: Low birth weight (LBW) is an independent risk factor of insulin
resistance and type 2 diabetes. Recent studies suggest that mitochondrial
dysfunction and impaired expression of genes involved in oxidative ... Cited by 7 - Related articles - All 3 versions
L Liang, V Mandal, Y Lu, D Kumar - BMC bioinformatics, 2008 - biomedcentral.com This paper proposes an innovative fuzzy-set-theory-based approach,
Multi-dimensional Cluster Misclassification test (MCM-test), to measure the
significance of gene pathways in a particular disease. Experiments have ... Cited by 5 - Related articles - Cached - All 7 versions
CM Frederiksen, K Højlund, L Hansen, EJ … - Diabetologia, 2008 - Springer Methods Using cDNA microarray technology and global pathway analysis with the
Gene Map Annotator and Pathway Profiler (GenMapp 2.1) and Gene Set Enrichment
Analysis (GSEA 2.0.1), we examined transcript levels in myotubes ... Cited by 2 - Related articles - All 2 versions
V Skov, D Glintborg, S Knudsen, Q Tan, T … - PLoS ONE, 2008 - pubmedcentral.nih.gov Insulin resistance is a common metabolic abnormality in women with PCOS and
leads to an elevated risk of type 2 diabetes. Studies have shown that
thiazolidinediones (TZDs) improve metabolic disturbances in PCOS patients. ... Cited by 3 - Related articles - All 6 versions
WI Sivitz, MA Yorek - Antioxidants & Redox Signaling - liebertonline.com Page 1. 1 COMPREHENSIVE INVITED REVIEW MITOCHONDRIAL DYSFUNCTION IN DIABETES: FROM
MOLECULAR MECHANISMS TO FUNCTIONAL SIGNIFICANCE AND THERAPEUTIC OPPORTUNITIES ... Related articles - All 3 versions
