- ►endojournals.org MY Donath, J Storling, LA Berchtold, N Billestrup, T … - Endocrine …, 2008 - Endocrine Soc The tale of cytokines and the β-cell is a long story, starting with in vitro discovery in 1984, evolving
via descriptive and phenomenological studies to detailed mapping of the signalling
pathways, gene- and protein expression patterns, molecular and biochemical effector ... Cited by 21 - Related articles - BL Direct - All 6 versions
MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is characterized by immune cell
invasion and local release of cytokines and chemokines and is sometimes accompanied by functional
or structural damage of the invaded tissue. It is not in itself a disease, but a manifestation ... Cited by 20 - Related articles - BL Direct - All 4 versions
P Marchetti, F Dotta, D Lauro, F Purrello - Regulatory Peptides, 2008 - Elsevier Type 2 diabetes is the most common form of diabetes in humans. It results from a combination
of factors that impair beta-cell function and tissue insulin sensitivity. However, growing evidence
is showing that the beta-cell is central to the development and progression of this form of ... Cited by 16 - Related articles - All 3 versions
- ►endojournals.org P Ribaux, JA Ehses, N Lin-Marq, F Carrozzino, M Boni- … - Endocrinology, 2007 - Endocrine Soc As we showed previously, the extracellular matrix (ECM) derived from rat bladder carcinoma
cells (804G-ECM) has positive effects on rat primary β-cell function and survival in vitro. The
aim of this study was to define β-cell genes induced by this ECM with a specific focus on ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►brighton.ac.uk [PDF] SJ Richardson, A Willcox, AJ Bone, AK Foulis, NG … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Evidence that the beta cells of human patients with type 1 diabetes
can be infected with entero- virus is accumulating, but it remains unclear whether such infections
occur at high frequency and are important in the disease process. We have now ... Cited by 13 - Related articles - All 4 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory
component. The latest studies indicate that innate immunity and inflammatory mediators have
a much broader role in T1DM than initially assumed. Inflammation might contribute to ... Cited by 8 - Related articles - All 8 versions
- ►endojournals.org M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical …, 2008 - Endocrine Soc Results: Gene array analysis of RNA from β-cells of individuals with T2DM revealed increased
expression of IL-1β mRNA. Real-time PCR confirmed increased IL-1β expression in six of 10
T2DM samples, with minimal or no expression in nine control samples. In cultured human ... Cited by 8 - Related articles - All 4 versions
A Willcox, SJ Richardson, AJ Bone, AK Foulis, … - Clin Exp …, 2009 - interscience.wiley.com The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because
of the limited availability of appropriate samples, but we now report a detailed study charting
the evolution of insulitis in human T1D. Pancreas samples removed post-mortem from 29 ... Cited by 6 - Related articles - All 3 versions
- ►numesi.com [PDF] B Portha, G Lacraz, M Kergoat, F Homo-Delarche, … - Molecular and Cellular …, 2009 - Elsevier Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of type
2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the possible mechanisms responsible
for abnormal islet microenvironment, decreased beta-cell number, impaired beta-cell ... Cited by 6 - Related articles - All 3 versions
- ►pnas.org H Ellingsgaard, JA Ehses, EB Hammar, L … - Proceedings of the …, 2008 - National Acad Sciences Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive factor to develop type
2 diabetes. Pancreatic islet pathology in type 2 diabetes is characterized by reduced β-cell function
and mass, an increased proportion of α-cells relative to β-cells, and α-cell dysfunction. ... Cited by 6 - Related articles - All 8 versions
