P Pirot, AK Cardozo, DL Eizirik - Arquivos Brasileiros de Endocrinologia & …, 2008 - SciELO Brasil Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from chronic
and progressive destruction of pancreatic beta-cells by the immune system. The triggering of
autoimmunity against the beta-cells is probably caused by environmental agent(s) acting ... Cited by 10 - Related articles - Cached - All 4 versions
CM Filippi, MG von Herrath - Diabetes, 2008 - Am Diabetes Assoc The most popular hypothesis circulating within and beyond the scientific community is that viral
infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can
injure β-cells and have been isolated in pancreatic tissues from diabetic patients. ... Cited by 8 - Related articles - All 8 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory
component. The latest studies indicate that innate immunity and inflammatory mediators have
a much broader role in T1DM than initially assumed. Inflammation might contribute to ... Cited by 8 - Related articles - All 8 versions
M von Herrath - Diabetes, 2009 - Am Diabetes Assoc We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play
a role in the development of type 1 diabetes to clinical interventions, where we will discuss novel
combination therapies. The role of viral infections in the development of type 1 diabetes is ... Cited by 8 - Related articles - All 10 versions
M Oikarinen, S Tauriainen, T Honkanen, K Vuori, P … - Diabetologia, 2008 - Springer Page 1. ARTICLE Analysis of pancreas tissue in a child positive for islet cell antibodies M.
Oikarinen & S. Tauriainen & T. Honkanen & K. Vuori & P. Karhunen & C. Vasama-Nolvi & S.
Oikarinen & C. Verbeke & GE Blair & I. Rantala & J. Ilonen & O. Simell & M. Knip & H. Hyöty ... Cited by 4 - Related articles - All 3 versions
R Uibo, A Lernmark - Immunopathogenesis of Type 1 Diabetes …, 2008 - books.google.com GAD65 Autoimmunity—Clinical Studies O j. Raivo Uibo* and Ake Lernmark Contents 1. Introduction
40 1.1. From 64K to GAD65 (1981-1991) 41 1.2. GAD65 and GAD67 structure and function 43
2. GAD65 Autoimmunity in T1D 48 2.1. Cellular GAD65 immunity in T1D 48 2.2. Humoral ... Cited by 2 - Related articles - All 2 versions
PD Campbell, E Estella, NL Dudek, G Jhala, HE … - Human Immunology, 2008 - Elsevier Cytotoxic T lymphocytes (CTL) are believed to play an essential role in β-cell destruction leading
to development of type 1 diabetes and allogeneic islet graft failure. We aimed to identify the mechanisms
used by CTL to kill human β cells. CTL clones that recognize epitopes from influenza ... Cited by 2 - Related articles - All 2 versions
S Diamantopoulos, G Allende, JM Ferreira, G … - Diabetes care, 2008 - Am Diabetes Assoc RESULTS—Four of 135 (2.96%) donors were AAb positive: three donors had GAD-AAb, and
one donor had insulin-AAb. Their respective recipients became insulin independent on
follow-up. Three of the four recipients had normal, insulin-producing grafts 3–5.8 years ... Cited by 1 - Related articles - All 8 versions
M Desai, A Clark - Diabetic Medicine, 2008 - interscience.wiley.com Latent autoimmune diabetes in adults (LADA) is characterised by a relatively mild diabetes
onset, autoantibody positivity and eventual requirement for insulin therapy. Twelve per cent of
newly diagnosed, UK Prospective Diabetes Study (UKPDS) patients were positive for ... Related articles - All 3 versions
G Fousteri, M von Herrath - Diabetes, 2008 - Am Diabetes Assoc Type 1 diabetes results from immune-mediated destruction of insulin-producing β-cells of the
pancreas. The disease manifests itself symptomatically when the resident β-cells become unable
to maintain normoglycemia. In human insulitis, mainly CD8 lymphocytes and B-cells, but ... Related articles - BL Direct - All 3 versions
