- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized
proteins destined for the cell surface or released into the extracellular milieu. The study of protein
folding and trafficking within the ER is an extremely active area of research that has ... Cited by 38 - Related articles - BL Direct - All 5 versions
B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of …, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic
β cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate
that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells ... Cited by 23 - Related articles - All 7 versions
- ►diabetesjournals.org MC Akerfeldt, J Howes, JY Chan, VA Stevens, N … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced by increased
phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation factor (EIF)2α, and Jun NH
2 -terminal kinase (JNK) and increased expression of activating transcription factor ... Cited by 9 - Related articles - All 3 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL Eizirik - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by modulation of
β-cell gene expression networks. The transcription factor Activator Protein-1 (AP-1) is a key regulator
of inflammation and apoptosis. We presently evaluated the function of the AP-1 subunit ... Cited by 8 - Related articles - All 7 versions
- ►diabetesjournals.org JA Corbett - Diabetes, 2008 - Am Diabetes Assoc The oxidation of glucose is required for the secretion of insulin by pancreatic β-cells. The product
of this oxidation, ATP, stimulates the closure of potassium channels and calcium-dependent
exocytosis of insulin. This system is beautifully regulated such that the precise amount of ... Cited by 5 - Related articles - BL Direct - All 3 versions
XQ Liu, L Wu, XJ Guo - World Journal of Gastroenterology: WJG, 2009 - pubmedcentral.nih.gov METHODS: Diabetes was induced by intraperitoneal injection of STZ at 55 mg/kg on day 1 and
day 8. Islet damage was evaluated using a scoring system. Nitrite, nitrate, α-mannosidase and
amylase activities were measured by colorimetry. N-glycan patterns of amylase were ... Related articles - All 9 versions
KJ Hughes, KT Chambers, GP Meares, … - American Journal of …, 2009 - Am Physiological Soc For many cell types, including pancreatic β-cells, nitric oxide is a mediator of cell death;
however, it is paradoxical that for a given cell type nitric oxide can induce both necrosis and
apoptosis. This report tests the hypothesis that cell death mediated by nitric oxide shifts ... Related articles - All 3 versions
I STOjANOvIć, D MAKSIMOvIć-IvANI, Y AL-AbeD, F … - KoBSON Insulin dependent type 1 diabetes (T1D) is a chronic inflammatory disorder characterized by
the autoim- mune destruction of pancreatic β cells. The autoim- mune reaction is a multistep
process triggered by interactions between immune cells and the islets (reviewed in K ... Related articles - View as HTML - All 2 versions
- ►nb.rs [PDF] I Stojanović, D Maksimović-Ivanić, Y Al-Abed, F … - Archives of Biological …, 2008 - CEON/ CEES Insulin dependent type 1 diabetes (T1D) is a chronic inflammatory disorder characterized by
the autoim- mune destruction of pancreatic β cells. The autoim- mune reaction is a multistep
process triggered by interactions between immune cells and the islets (reviewed in K ... Related articles - View as HTML