L Adorini, G Penna - Nature Clinical Practice Rheumatology, 2008 - nature.com Dr Luciano Adorini is Chief Scientific Officer at Intercept Pharmaceuticals, Corciano
(Perugia), and formerly held the same position at BioXell, Milan, Italy. He obtained his medical
degree from the University of Padova, Italy, in 1974. Dr Adorini has studied several ... Cited by 36 - Related articles - All 3 versions
- ►endojournals.org R Bouillon, G Carmeliet, L Verlinden, E van Etten, A … - Endocrine …, 2008 - Endocrine Soc The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin
D [1,25-(OH) 2 D], can now be better evaluated by critical analysis of mice with ... Cited by 35 - Related articles - All 6 versions
JR Wu-Wong - British Journal of Pharmacology, 2009 - interscience.wiley.com Vitamin D 3 is made in the skin and modified in the liver and kidney to form the active
metabolite, 1,25-dihydroxyvitamin D 3 (calcitriol). Calcitriol binds to a nuclear receptor, the vitamin
D receptor (VDR), and activates VDR to recruit cofactors to form a transcriptional complex ... Cited by 3 - Related articles - All 3 versions
NM Maalouf - Current Opinion in Nephrology and Hypertension, 2008 - journals.lww.com Introduction The major sources of vitamin D in humans are cutaneous synthesis, diet, and
supplements. The initial step in vitamin D metabolism involves its hepatic hydroxylation, generating
25-hydroxyvitamin D (25-OH-D). 25-OH-D has a half-life in circulation of approximately 2 ... Cited by 1 - Related articles - All 6 versions
DD Bikle - Current Osteoporosis Reports, 2009 - Springer Vitamin D, acting through its active metabolite 1,25(OH)2D3, exerts its influence on many
physi- ologic processes in addition to the regulation of calcium and phosphate homeostasis.
These processes include the immune system. Both the adaptive and innate immune ... Cited by 1 - Related articles - All 2 versions
DB Mory, ER Rocco, WL Miranda, T Kasamatsu, F … - Human Immunology, 2009 - Elsevier The effect of the vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes
(T1DM) is heterogeneous. Genetic factors may also influence the residual β-cell function. We
studied the frequency of VDR FokI (rs10735810) and BsmI (rs154410) polymorphisms in ... Related articles
T Kaya, N Swamy, KS Persons, S Ray, SC Mohr, R Ray - Bioorganic Chemistry, 2009 - Elsevier Structure–functional characterization of vitamin D receptor (VDR) requires identification of structurally
distinct areas of VDR-ligand-binding domain (VDR-LBD) important for biological properties of
1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ). We hypothesized that covalent attachment ... Related articles - All 2 versions
RD Motrich, E van Etten, J Depovere, CM Riera, VE … - Journal of Autoimmunity, 2009 - Elsevier Chronic non bacterial prostatitis is a chronic inflammatory syndrome. Its etiology and physiopathology
are unclear and treatments are empirical and ineffective in most cases. Autoimmunity has been
proposed as an etiology. In the present report, we investigated the impact of vitamin D ... Related articles - All 5 versions
DD Bikle - Clinical Reviews in Bone and Mineral Metabolism - Springer Abstract Although the best known actions of vitamin D involve its regulation of bone mineral
homeostasis, actions critical for a healthy skeleton, vitamin D exerts its influence on many physiologic
processes. One of these processes is the immune system. Both the adaptive and innate ... Related articles