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Rgs5 targeting leads to chronic low blood pressure and a lean body habitus

- nih.gov
H Cho, C Park, IY Hwang, SB Han, D Schimel, … - Molecular and Cellular Biology, 2008 - Am Soc Microbiol
RGS5 is a potent GTPase-activating protein for G i and G q that is expressed
strongly in pericytes and is present in vascular smooth muscle cells. To study
the role of RGS5 in blood vessel physiology, we generated Rgs5-deficient ...
Cited by 8 - Related articles - BL Direct - All 8 versions

Novel peptide ligands of RGS4 from a focused one-bead, one-compound library


R Roof, K Sobczyk-Kojiro, A Turbiak, D … - Chemical Biology and Drug Design, 2008 - interscience.wiley.com
Regulators of G protein signaling accelerate GTP hydrolysis by Gα subunits and
profoundly inhibit signaling by G protein-coupled receptors. The distinct
expression patterns and pathophysiologic regulation of regulators of G ...
Cited by 5 - Related articles - All 3 versions

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR …

- cell.com
M Jayaraman, H Zhou, L Jia, MD Cain, KJ … - Trends in Pharmacological Sciences, 2009 - Elsevier
RGS (regulator of G protein signaling) proteins have emerged as crucial
regulators, effectors and integrators in G-protein-coupled receptor (GPCR)
signaling networks. Many RGS proteins accelerate GTP hydrolysis by Gα ...
Cited by 4 - Related articles - All 3 versions

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current …


LL Blazer, RR Neubig, 2008 - nature.com
Protein–protein interactions are a crucial element in cellular function. The
wealth of information currently available on intracellular-signaling pathways
has led many to appreciate the untapped pool of potential drug targets that ...
Cited by 3 - Related articles - All 3 versions

Structure and Function of Regulator of G Protein Signaling Homology Domains


JJG Tesmer - Molecular Biology of RGS Proteins, 2009 - books.google.com
Structure and Function of Regulator of G Protein Signaling Homology Domains John
JG Tesmer Department of Pharmacology, Life Sciences Institute, University of
Michigan, Ann Arbor, Michigan 48109‐2216 I. Introduction.................. ...
Cited by 1 - Related articles

Identification of Ligands Targeting RGS Proteins: High‐Throughput Screening and …


DL Roman - Molecular Biology of RGS Proteins, 2009 - books.google.com
Identification of Ligands Targeting RGS Proteins: High‐Throughput Screening
and Therapeutic Potential David L. Roman Division of Medicinal and Natural
Products Chemistry, The University of Iowa College of Pharmacy, Iowa City, ...
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