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Scholar Results 1 - 10 of 11 citing Morino: Muscle-specific IRS-1 Ser-> Ala transgenic mice are protected from fat-induced insulin.... (0.10 sec) 

Phosphorylation of IRS proteins, insulin action, and insulin resistance


S Boura-Halfon, Y Zick - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc
Insulin signaling at target tissues is essential for growth and development and
for normal homeostasis of glucose, fat, and protein metabolism. Control over
this process is therefore tightly regulated. It can be achieved by a ...
Cited by 6 - Related articles - All 3 versions

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence …


R Ragheb, GML Shanab, AM Medhat, DM … - Biochemical and Biophysical Research …, 2009 - Elsevier
In the present study, we examined the effects of free fatty acids (FFAs) on
insulin sensitivity and signaling cascades in the C2C12 skeletal muscle cell
culture system. Our data clearly manifested that the inhibitory effects of ...
Cited by 1 - Related articles - All 2 versions

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and …


JF Tanti, J Jager - Current Opinion in Pharmacology, 2009 - Elsevier
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled
physiological feedback mechanism in insulin signaling that is hijacked by
metabolic and inflammatory stresses to promote insulin resistance. Kinases, ...
Cited by 1 - Related articles - All 2 versions

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, …

- angrylapdog.com
SJ Peterson, DH Kim, M Li, V Positano, L … - The Journal of Lipid Research, 2009 - ASBMB
We examined mechanisms by which L-4F reduces obesity and diabetes in obese (ob)
diabetic mice. We hypothesized that L-4F reduces adiposity via increased pAMPK,
pAKT, HO-1, and increased insulin receptor phosphorylation in ob mice. ...
Related articles - All 8 versions

Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta-cells from TNF-alpha …


K Bouzakri, P Ribaux, PA Halban - Journal of Biological Chemistry, 2009 - ASBMB
Obesity and type 2 diabetes present partially overlapping phenotypes with
systemic inflammation as a common feature, raising the hypothesis that elevated
cytokine levels may contribute to peripheral insulin resistance as well as ...
Related articles - All 3 versions

PPARs and the orchestration of metabolic fuel selection


MC Sugden, MG Zariwala, MJ Holness - Pharmacological Research, 2009 - Elsevier
This contribution describes recent advances in our knowledge of the regulatory
interactions between the two major oxidative fuels glucose and lipid. It also
addresses how the metabolic abnormalities associated with insulin ...
Related articles - All 2 versions

Heat shock proteins: Novel therapeutic targets against insulin resistance and type 2 …

- ku.edu [PDF] 
AA Gupte, 2009 - kuscholarworks.ku.edu
Submitted to the graduate degree program in Molecular and Integrative Physiology
and the Graduate Faculty of the University of Kansas in partial fulfillment of
the requirements for the degree of Doctor of Philosophy
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Role of muscle JNK1 in obesity-induced insulin resistance


G Sabio, NJ Kennedy, J Cavanagh-Kyros, DY … - Molecular and Cellular Biology, 2009 - Am Soc Microbiol
Page 1. Guadalupe Sabio Page 1 Role of muscle JNK1 in obesity-induced insulin
resistance Running Title: Mice with muscle-specific JNK1-deficiency ...
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[CITATION] 31 Insulin Resistance


VT Samuel, KF Petersen, GI Shulman
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The Randle cycle revisited: a new head for an old hat


L Hue, H Taegtmeyer - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc
In 1963, Lancet published a paper by Randle et al. that proposed a
"glucose-fatty acid cycle" to describe fuel flux between and fuel selection by
tissues. The original biochemical mechanism explained the inhibition of ...
Related articles - All 3 versions


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