LA Crawford, MA Guney, YA Oh, RA DeYoung, … - Molecular …, 2009 - Endocrine Soc The factors necessary for normal pancreatic islet morphogenesis have not been well
characterized. Here we report that connective tissue growth factor (CTGF) is involved in the establishment
of normal islet endocrine cell ratio and architecture. CTGF is a secreted protein known to ... Cited by 2 - Related articles - All 3 versions
X Wu, L Wang, S Schroer, D Choi, P Chen, H Okada, M … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Pancreatic beta cells undergo dynamic remodelling during the perinatal
period, with enhanced neogenesis, proliferation and apoptosis observed. The molecular mechanisms
responsible for these processes have yet to be elucidated. Survivin is an inhibitor of ... Related articles - All 2 versions
J Xu, YS Long, D Gozal, PN Epstein - Free Radical Biology and Medicine, 2009 - Elsevier Intermittent hypoxia (IH), such as occurs in sleep apnea, induces increased oxidative stress and
is associated with altered glucose homeostasis. Because pancreatic β cells are very sensitive
to oxidative stress we tested whether they could be affected by IH. The effects of IH ... Cited by 1 - Related articles - All 2 versions
S Rieck, P White, J Schug, AJ Fox, O Smirnova, … - Molecular …, 2009 - Endocrine Soc The inability of the ß-cell to meet the demand for insulin brought about by insulin resistance leads
to type 2 diabetes. In adults, ß-cell replication is one of the mechanisms thought to cause the
expansion of ß-cell mass. Efforts to treat diabetes require knowledge of the pathways that ... Related articles - All 3 versions