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Scholar Results 1 - 10 of about 15 citing Asleh: Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype. (0.07 sec) 

Haptoglobin genotype is a major determinant of the amount of iron in the human …

- onlinejacc.org
… Moreno, KR Purushothaman, M Purushothaman, P … - Journal of the American …, 2008 - Elsevier
In atherosclerotic lesions, intraplaque hemorrhage releases free hemoglobin (Hb), whose incorporated
iron can act as an oxidant and inflammatory stimulus. These effects are antagonized by Hp, which
binds free Hb and facilitates its clearance from the plaque. The Hp gene has 2 alleles (1 ...
Cited by 8 - Related articles - All 19 versions

Pharmacogenomic application of the haptoglobin genotype in the prevention of …


S Blum, U Milman, C Shapira, AP Levy - Pharmacogenomics, 2008 - Future Medicine
The public health and economic burdens from diabetes mellitus (DM) are presently staggering
and are becoming more severe. Morbidity and mortality from DM is due to the effect of DM on
the cardiovascular system. Accelerated atherosclerosis and its sequalae are by far the ...
Cited by 3 - Related articles - All 3 versions

Hemoglobin and its scavenger protein haptoglobin associate with apoA-1 …


J Watanabe, V Grijalva, S Hama, K Barbour, F … - Journal of Biological …, 2009 - ASBMB
Page 1. Hemoglobin, haptoglobin and hemopexin play a role in HDL inflammatory properties
1 Hemoglobin and its scavenger protein haptoglobin associate with apoA-1 containing particles
and influence the inflammatory properties and function of high density lipoprotein ...
Cited by 2 - Related articles - All 3 versions

Toxicological Consequences of Extracellular Hemoglobin: Biochemical and …


PW Buehler, F D'Agnillo - Antioxidants & Redox Signaling - liebertonline.com
Page 1. Buehler 1 FORUM REVIEW Toxicological Consequences of Extracellular Hemoglobin:
Biochemical and Physiological Perspectives Paul W. Buehler and Felice D'Agnillo Laboratory
of Biochemistry and Vascular Biology, Division of Hematology, Center ...
Cited by 1 - Related articles - All 3 versions

Promoting Mechanisms of Vascular Health Circulating Progenitor Cells, …


PR Moreno, J Sanz, V Fuster - Journal of the American College of Cardiology, 2009 - Elsevier
To understand and promote vascular health, we must reduce the aggression to the vessel wall
and enhance the physiologic mechanisms leading to restoration of vessel wall function. Three
main defense mechanisms are responsible for maintaining cardiovascular homeostasis: ...
Cited by 1 - Related articles - All 17 versions

Reconstituted High-Density Lipoprotein Increases Plasma High-Density …


S Patel, BG Drew, S Nakhla, SJ Duffy, AJ Murphy, … - Journal of the American …, 2009 - Elsevier
Thirteen fasting male patients (mean age 52 years) with type 2 diabetes mellitus received both
rHDL (80 mg/kg of apolipoprotein AI) and a saline placebo on separate occasions in a randomized
cross-over design study. Changes in the ability of isolated HDL to influence the ...
Cited by 3 - Related articles - All 5 versions

Haptoglobin: basic and clinical aspects


A Levy, R Asleh, S Blum, N Levy, R Miller-Lotan, … - Antioxidants & Redox … - liebertonline.com
Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function
of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells
after either intravascular or extravascular hemolysis. There are two common alleles at the ...
Cited by 1 - Related articles - All 3 versions

Pharmacogenomics and the prevention of vascular complications in diabetes …


D Farbstein, AP Levy - Therapy, 2009 - Future Medicine
While the majority of patients benefit from front-line therapies for diabetes and dyslipidemia, others
present with diminished responses. These differences in drug efficacy appear to be due, in large
part, to genetic polymorphisms affecting pharmacokinetics and drug-target interactions. ...
Cited by 1 - Related articles - All 3 versions

Controlled Delivery of Nitric Oxide Inhibits Leukocyte Migration and Prevents …


EN Momin, KE Schwab, KL Chaichana, R Miller-Lotan, … - Neurosurgery, 2009 - journals.lww.com
Page 1. NEUROSURGERY VOLUME 65 | NUMBER 5 | NOVEMBER 2009 | 937
EXPERIMENTAL STUDY Eric N. Momin, BA Department of Neurosurgery, The Johns
Hopkins University School of Medicine, Baltimore, Maryland ...
Related articles - All 2 versions

[PDF] Haptoglobin (HP) Genotyping


T Highlights - arupbdm.com
Haptoglobin (HP) functions as a hemoglobin-binding protein • conserving the iron released following
red cell hemolysis, thus preventing kidney damage. HP is composed of an alpha and beta
chain. The alpha chain • is represented by two common alleles (Hp 1 and Hp 2), while the ...
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