B Viollet, L Lantier, J Devin-Leclerc, S … - Frontiers in …, 2009 - pubmedcentral.nih.gov Type 2 diabetes is one of the fastest growing public health problems worldwide resulting from
both environmental and genetic factors. It is characterized by the abnormal glucose and lipid
metabolism due in part to resistance to the actions of insulin in skeletal muscle, liver and ... Cited by 5 - Related articles - All 4 versions
BD Hegarty, N Turner, GJ Cooney, EW … - Acta …, 2009 - interscience.wiley.com The worldwide prevalence of type-2 diabetes (T2D) and related disorders of the Metabolic Syndrome
(MS) has reached epidemic proportions. Insulin resistance is a major perturbation that characterises
these disorders. Extra-adipose accumulation of lipid, particularly within the liver and ... Related articles - All 3 versions
JR Ussher, JS Jaswal, CS Wagg, HE … - American Journal of …, 2009 - Am Physiological Soc During metabolic stress, phosphorylation and activation of 5'-AMP-activated protein kinase
(AMPK) becomes a major regulator of cellular energy metabolism in heart and skeletal
muscle. Despite this, the upstream regulation of AMPK in both heart and muscle is poorly ... Related articles - All 2 versions
TE Jensen, JFP Wojtaszewski, EA … - Acta physiologica (Oxford …, 2009 - interscience.wiley.com In skeletal muscle, the contraction-activated heterotrimeric 5' AMP-activated protein kinase
(AMPK) protein is proposed to regulate the balance between anabolic and catabolic processes
by increasing substrate uptake and turnover in addition to regulating the transcription of ... Related articles - All 3 versions
S Beck Jørgensen, HM O'Neill, K Hewitt, BE Kemp, GR … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Obesity-related insulin resistance is associ- ated with accumulation
of bioactive lipids in skeletal muscle. The AMP-activated protein kinase (AMPK) regulates lipid
oxidation in muscle by inhibiting acetyl-CoA carboxylase-2 (ACC2) and increasing ... Related articles - All 2 versions