B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of …, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic
β cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate
that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells ... Cited by 23 - Related articles - All 7 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL Eizirik - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by modulation of
β-cell gene expression networks. The transcription factor Activator Protein-1 (AP-1) is a key regulator
of inflammation and apoptosis. We presently evaluated the function of the AP-1 subunit ... Cited by 8 - Related articles - All 7 versions
RL Hull, S Zraika, J Udayasankar, K Aston-Mourney, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Supraphysiological levels of the amyloi- dogenic peptide human islet
amyloid polypeptide have been associated with beta cell endoplasmic reticulum (ER) stress.
However, in human type 2 diabetes, levels of human IAPP are equivalent or decreased ... Cited by 1 - Related articles - All 2 versions
G Szabadkai, MR Duchen - Apoptosis - Springer Abstract Mitochondrial dysfunction plays a role in the pathogenesis of a wide range of diseases
that involve dis- ordered cellular fuel metabolism and survival/death path- ways, including neurodegenerative
diseases, cancer and diabetes. Cytokine, virus recognition and cellular stress pathways ... Related articles - All 2 versions
JC Jonas, M Bensellam, J Duprez, H … - Diabetes, Obesity …, 2009 - interscience.wiley.com Pancreatic β-cells exposed to high glucose concentrations display altered gene expression,
function, survival and growth that may contribute to the slow deterioration of the functional β-cell
mass in type 2 diabetes. These glucotoxic alterations may result from various types of ... Related articles - All 2 versions
EN Gurzov, F Ortis, DA Cunha, G Gosset, M Li, AK … - Cell Death & …, 2009 - nature.com Chronic inflammation and pro-inflammatory cytokines are important mediators of pancreatic
-cell destruction in type 1 diabetes (T1D). We presently show that the cytokines IL-1 +IFN- and
different ER stressors activate the Bcl-2 homology 3 (BH3)-only member death protein 5 ( ... Related articles - All 3 versions
… G Dharmadhikari, DM Schumann, J Størling - Expert Opin. Biol. …, 2009 - informahealthcare.com Since having been cloned in 1984, IL-1β has been the subject of over 22,000 citations in
Pubmed, among them over 800 reviews. This is because of its numerous effects. IL-1β is a regulator
of the body's inflammatory response and is produced after infection, injury, and antigenic ... Related articles - All 6 versions
MF Tonnesen, LG Grunnet, J Friberg, AK Cardozo, N … - Endocrinology, 2009 - Endocrine Soc Accumulating evidence suggests that endoplasmic reticulum (ER) stress by mechanisms that
include ER Ca 2+ depletion via NO-dependent down-regulation of sarcoendoplasmic reticulum
Ca 2+ ATPase 2b (SERCA2b) contributes to β-cell death in type 1 diabetes. To clarify ... Related articles
CJH van der Kallen, MMJ van Greevenbroek, CDA … - Apoptosis - Springer Abstract Diabetes mellitus (DM) is a multifactorial chronic metabolic disease characterized by
hyperglyca- emia. Several different mechanisms have been implicated in the development of
the disease, including endoplasmic reticulum (ER) stress. ER stress is increasingly ... Related articles - All 2 versions