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Scholar Results 1 - 5 of 5 citing Marzban: Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression.... (0.11 sec) 

Sphingomyelinase dependent apoptosis following treatment of pancreatic beta- …


Y Zhang, F Ranta, C Tang, E Shumilina, H Mahmud, M … - Apoptosis, 2009 - Springer
Abstract Amyloid peptides interfere with survival of pancreatic beta-cells. In some cells apoptosis
is paralleled by ceramide-dependent alterations of ion channel activity. The purpose of the present
study was to elucidate the dependence of amyloid peptides Aß 1-42 and islet amyloid ...
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Vascular niche of pancreatic islets


J Olerud, A Johansson, PO Carlsson - Expert Review of …, 2009 - ingentaconnect.com
Since the different endocrine cell types have dis- tinct locations in the rodent pancreas, with
b-cells mainly located in the core region, the direction of intra-islet blood perfusion has been
proposed to have significant impact on cell intercommu- nication within the islet. ...
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Amyloid inhibitors enhance survival of cultured human islets


KJ Potter, LA Scrocchi, GL Warnock, Z Ao, MA Younker, … - BBA-General Subjects, 2009 - Elsevier
Amyloid fibrils created by misfolding and aggregation of proteins are a major pathological feature
in a variety of degenerative diseases. Therapeutic approaches including amyloid vaccines and
anti-aggregation compounds in models of amyloidosis point to an important role for ...
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β-cell death and proliferation after intermittent hypoxia: Role of oxidative stress


J Xu, YS Long, D Gozal, PN Epstein - Free Radical Biology and Medicine, 2009 - Elsevier
Intermittent hypoxia (IH), such as occurs in sleep apnea, induces increased oxidative stress and
is associated with altered glucose homeostasis. Because pancreatic β cells are very sensitive
to oxidative stress we tested whether they could be affected by IH. The effects of IH ...
Cited by 1 - Related articles - All 2 versions

人类疾病发生的表观遗传机制及治疗研究进展


赵方允, 刘侃 - 广东药学院学报, 2009 - journal.shouxi.net
哺乳动物雌性个体不论有多少条X染色体,最终只能随机保留一条的活性。X染色体失活由X失活中心
(Xic)调控,Xic调控X染色体失活特异性转录基因(Xist)的表达。X染色体的不对称失活可导致多种疾病
,例如男性发病率较高的WiskottAldrich综合征是由于WASP基因突变所致。X染色体的PLP ...
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