M van Eijk, J Aten, N Bijl, R Ottenhoff, … - PLoS One, 2009 - pubmedcentral.nih.gov Adipose tissue is a critical mediator in obesity-induced insulin resistance.
Previously we have demonstrated that pharmacological lowering of
glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, ... Cited by 7 - Related articles - All 6 versions
J Tordjman, M Guerre-Millo, K Clément - Diabetes and Metabolism, 2008 - Elsevier The increase in circulating inflammatory factors found in obese subjects and the
recent discovery of macrophage infiltration in white adipose tissue (WAT) have
opened up new fields of investigation, allowing a reevaluation of the ... Cited by 4 - Related articles - All 2 versions
PA Permana, W Zhang, M Wabitsch, P … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Infiltration of monocyte-derived macrophages into adipose tissue may contribute
to tissue and systemic inflammation and insulin resistance. We hypothesized that
pioglitazone (Pio) could specifically reduce the inflammatory response of ... Cited by 1 - Related articles - All 3 versions
ASD Molgat, AM Gagnon, A Sorisky - American Journal of Physiology- Cell Physiology, 2009 - Am Physiological Soc Obesity is associated with macrophage accumulation and inflammation in adipose
tissue. Macrophage-secreted factors have been reported to inhibit the
differentiation of preadipocytes into adipocytes and to modulate adipogenic ... Cited by 1 - Related articles - All 3 versions
DE Lee, S Kehlenbrink, H Lee, M Hawkins, JS … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Obesity is associated with resistance of skeletal muscle to insulin-mediated
glucose uptake, as well as resistance of different organs and tissues to other
metabolic and vascular actions of insulin. In addition, the body is ... Cited by 1 - Related articles - All 3 versions
- ►dartmouthjournals.com [PDF] SH Chiang, M Bazuine, CN Lumeng, LM Geletka, … - Cell, 2009 - Elsevier Obesity is associated with chronic low-grade inflammation that negatively
impacts insulin sensitivity. Here, we show that high-fat diet can increase
NF-κB activation in mice, which leads to a sustained elevation in level of ... Related articles - All 7 versions
PJ Bilan, V Samokhvalov, A Koshkina, JD …, 2009 - Informa Pharma Science Obesity is associated with insulin resistance and increased risk for developing
type 2 diabetes. Enlarged adipocytes develop resistance to the anti-lipolytic
action of insulin. Elevated levels of fatty acids in the plasma and ... Related articles - All 5 versions
X Prieur, T Rőszer, M Ricote - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier Accumulation of lipid metabolites within non-adipose tissues can induce chronic
inflammation by promoting macrophage infiltration and activation. Oxidized and
glycated lipoproteins, free fatty acids, free cholesterol, ... Related articles - All 2 versions
M West - Current Opinion in Endocrinology, Diabetes and …, 2009 - journals.lww.com Recent findings: In mice, there is recent progress in understanding the
differences in distribution of two distinct phenotypes of ATM classes with
respect to dead adipocytes. Furthermore, a detailed atlas of fat ... Related articles - All 5 versions
