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Scholar Results 1 - 2 of 2 citing Chen: Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1α (HIF-1α)-Prolyl-4-Hydroxylase-2,.... (0.07 sec) 

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx …


K De Bock, F De Smet, R Leite De Oliveira, K … - Journal of Molecular Medicine, 2009 - Springer
Abstract An ancestral function of vessels is to conduct blood flow and supply
oxygen (O 2 ). In hypoxia, cells secrete angiogenic factors to initiate vessel
sprouting. Angiogenic factors are balanced off by inhibitors, ensuring that ...
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The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial …


L Kugathasan, JB Ray, Y Deng, E Rezaei, DJ … - Journal of Experimental Medicine, 2009 - jem.rupress.org
The role of the angiopoietin-1 (Ang1)–Tie2 pathway in the pathogenesis of
pulmonary arterial hypertension (PAH) is controversial. Although Ang1 is well
known to prevent endothelial activation and injury in systemic vascular ...
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