- ►endojournals.org M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical …, 2008 - Endocrine Soc Results: Gene array analysis of RNA from β-cells of individuals with T2DM revealed increased
expression of IL-1β mRNA. Real-time PCR confirmed increased IL-1β expression in six of 10
T2DM samples, with minimal or no expression in nine control samples. In cultured human ... Cited by 8 - Related articles - All 4 versions
E Zigmond, SW Zangen, O Pappo, M … - American Journal of …, 2009 - Am Physiological Soc A link between altered levels of various gangliosides and the development of insulin resistance
was described in transgenic mice. Naturally occurring glycosphingolipids were shown to exert
immunomodulatory effects in a natural killer T (NKT) cell-dependent manner. This study ... Cited by 5 - Related articles - All 3 versions
J Ehses, M Boni-Schnetzler, M Faulenbach … - Biochemical Society …, 2008 - biochemsoctrans.org The pathology of islets from patients with Type 2 diabetes displays an inflammatory process characterized
by the presence of immune cell infiltration, cytokines, apoptotic cells, amyloid deposits and,
eventually, fibrosis. Indeed, analysis of β-cells from patients with Type 2 diabetes displays ... Cited by 3 - Related articles - Cached - BL Direct - All 4 versions
S Ryu, A Ornoy, A Samuni, S Zangen, R Kohen - Metabolism, 2008 - Elsevier Increased oxidative stress contributes to the development and progression of both types of diabetes
mellitus (DM) and its complications. In the Cohen diabetic (CD) rats, a known genetic model
of nutritionally induced type 2 DM, a high-sucrose, low-copper diet (HSD) induces within ... Cited by 4 - Related articles - All 21 versions
- ►endojournals.org [PDF] M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical …, 2008 - Endocrine Soc 1 Clinic of Endocrinology and Diabetes, University Hospital of Zurich, 8091 Zurich, Switzerland
2 Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical
School, Boston, Massachusetts 02215, USA 3 Department of Genetic Medicine and ... Cited by 1 - Related articles
M Böni-Schnetzler, JA Ehses, M … - Diabetes, Obesity …, 2008 - interscience.wiley.com Islets of patients with type 2 diabetes have the feature of an inflammatory process reflected by
the presence of cytokines, immune cells, β-cell apoptosis, amyloid deposits and fibrosis.
Indeed, β-cells from patients with type 2 diabetes display inflammatory markers, including ... Cited by 2 - Related articles - All 2 versions
JA Ehses, H Ellingsgaard, M Böni-Schnetzler, MY … - 2009 - Informa Pharma Science Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of β
cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 diabetic
patients and rodent models of the disease indicate the increased presence of IL-1 driven ... Related articles - All 5 versions
… G Dharmadhikari, DM Schumann, J Størling - Expert Opin. Biol. …, 2009 - informahealthcare.com Since having been cloned in 1984, IL-1β has been the subject of over 22,000 citations in
Pubmed, among them over 800 reviews. This is because of its numerous effects. IL-1β is a regulator
of the body's inflammatory response and is produced after infection, injury, and antigenic ... Related articles - All 6 versions