M Kebede, T Alquier, MG Latour, M Semache, C … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic β-cells and
is activated by long-chain fatty acids. Gene deletion studies have shown that GPR40
mediates, at least in part, fatty acid–amplification of glucose-induced insulin secretion ... Cited by 13 - Related articles - All 4 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell …, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of elevated
glucose, and fatty acid levels on pancreatic beta-cell function and survival. Significant progress
has been made in recent years towards a better understanding of the cellular and ... Cited by 9 - Related articles - BL Direct - All 4 versions
V Poitout - Biochemical Society Transactions, 2008 - biochemsoctrans.org The glucolipotoxicity hypothesis postulates that chronically elevated levels of glucose and fatty
acids adversely affect pancreatic β-cell function and thereby contribute to the deterioration of
insulin secretion in Type 2 diabetes. Whereas ample experimental evidence in in vitro ... Cited by 2 - Related articles - Cached - All 5 versions
G Fontés, M Semache, DK Hagman, C Tremblay, R … - Diabetes, 2009 - biochem.utah.edu Involvement of Per-Arnt-Sim Kinase and ... Inhibition of Insulin Gene Expression in Pancreatic
ß-Cells ... Ghislaine Fontés,1,2 Meriem Semache,1 Derek K. Hagman,1,2 Caroline
Tremblay,1 Ramila Shah,3 Christopher J. Rhodes,3 Jared Rutter,4 and Vincent Poitout1,2 Related articles - View as HTML - All 4 versions
K Fujimoto, KS Polonsky - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com A progressive reduction in β-cell mass occurs in the evolution of diabetes. Thus understanding
the mechanisms responsible for this reduction in β-cell mass is important for understanding the
pathogenesis of diabetes and in developing novel approaches to prevention and ... Related articles - All 3 versions