- ►diabetesjournals.org MR Dasu, S Devaraj, L Zhao, DH Hwang, I Jialal - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Pharmacological inhibition of protein kinase C (PKC) activity and NADPH oxidase
significantly decreased TLR2 and TLR4 mRNA and protein (P < 0.05). Knocking down both TLR2
and TLR4 in the cells resulted in a 76% (P < 0.05) decrease in high-glucose–induced ... Cited by 15 - Related articles - All 6 versions
N Bashan, J Kovsan, I Kachko, H Ovadia, A … - Physiological …, 2009 - Am Physiological Soc Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) adequately
balanced by antioxidant systems is a prerequisite for the participation of these active substances
in physiological processes, including insulin action. Yet, increasing evidence implicates ... Cited by 7 - Related articles - All 3 versions
P Fioretto, ML Caramori, M Mauer - Diabetologia, 2008 - Springer Abstract Diabetic nephropathy is the most common cause of end-stage renal disease
(ESRD). The natural history of diabetic nephropathy has changed over the last decades, as a
consequence of better metabolic and blood pressure management. Thus, it may now be ... Cited by 6 - Related articles - All 3 versions
- ►cardiovascres.org L Gao, GE Mann - Cardiovascular Research, 2009 - cardiovascres.oxfordjournals.org Oxidative stress mediated by hyperglycaemia-induced generation of reactive oxygen species
(ROS) contributes significantly to the development and progression of diabetes and related vascular
complications. NAD(P)H oxidase has been implicated as the major source of ROS ... Cited by 8 - Related articles - All 6 versions
- ►physiology.org [PDF] XF Wei, QG Zhou, FF Hou, BY Liu, M … - American Journal of …, 2008 - Am Physiological Soc Page 1. 1 1 Advanced oxidation protein products induce mesangial cells perturbation
through PKC-dependent activation of NADPH oxidase Xiao Fan Wei*2, Qiu Gen
Zhou*2, Fan Fan Hou*1, Bei Yi Liu†, Min Liang* Southern ... Cited by 6 - Related articles - All 3 versions
JA Nogueira-Machado, MM Chaves - Expert opinion on …, 2008 - informahealthcare.com Background: Diabetes mellitus constitutes a serious public health problem. Recent advances
in therapies are unable to control its vascular complications. New medications have been suggested
but without comprehensive knowledge of the signaling pathways induced by ... Cited by 3 - Related articles - All 7 versions
M Meier, J Menne, H Haller - Diabetologia, 2009 - Springer Abstract The protein kinase C (PKC) superfamily com- prises proteins that are activated in response
to various pathogenic stimuli in the diabetic state. Hyperglycaemia is the predominant stimulus
that induces the activation of distinct PKC isoforms within a cell, each mediating specific ... Cited by 3 - Related articles - All 2 versions
KR Tuttle, RJ Anderberg, SK Cooney, RL … - American Journal of …, 2008 - content.karger.com Background/Aims: High levels of glucose and/or amino acids increase advanced glycation end
products (AGE) and activate protein kinase C (PKC), a key signal for injury in mesangial
cells. The aim was to determine whether oxidative stress mediates bidirectional ... Cited by 3 - Related articles - All 4 versions
- ►iovs.org MP Cohen, E Hud, VY Wu, CW Shearman - Investigative Ophthalmology & Visual …, 2008 - ARVO PURPOSE. Albumin modified by Amadori glucose adducts is a plasma-borne factor that activates
cell signaling pathways, modulates the expression of growth factors and cytokines, and participates
in the pathogenesis of microvascular complications of diabetes. In the present study, ... Cited by 2 - Related articles - All 3 versions
