DN Gross, M Wan, MJ Birnbaum - Current Diabetes Reports, 2009 - Springer Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic
func- tions. FOXO is regulated by several modifications, but one of the most critical is phosphorylation
and nuclear exclusion by Akt. Given the impact of insu- lin signaling on Akt-mediated ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►bentham.org [PDF] S Pillarisetti - Recent Patents on Cardiovascular Drug Discovery, 2008 - ingentaconnect.com Received: June 30, 2008; Accepted: August 13, 2008; Revised: August 20, 2008 Abstract: Sirt1
(member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase
that removes acetyl groups from various proteins. A wide variety of proteins are Sirt1 ... Cited by 6 - Related articles - All 6 versions
Y Ito, H Daitoku, A Fukamizu - Biochemical and Biophysical Research …, 2008 - Elsevier Obesity is associated with a low-grade inflammation in adipose tissue resulting from increased
production of pro-inflammatory cytokines and which can subsequently contribute to the development
of insulin resistance. However, the mechanisms underlying the transcriptional regulation ... Cited by 3 - Related articles - All 3 versions
A Kamagate, HH Dong - Cell cycle (Georgetown, Tex.), 2008 - pubmedcentral.nih.gov Very low-density lipoproteins (VLDL) are triglyceride-rich particles. VLDL is synthesized in hepatocytes
and secreted from the liver in a pathway that is tightly regulated by insulin. Hepatic VLDL production
is stimulated in response to reduced insulin action, resulting in increased release of VLDL ... Cited by 3 - Related articles - All 4 versions
I Gerin, GT Bommer, ME Lidell, A Cederberg, S … - Journal of Biological …, 2009 - ASBMB In this study, we explore the effects of several FOX and mutant FOX transcription factors on adipocyte
determination, differentiation, and metabolism. In addition to Foxc2 and Foxo1, we report that
Foxf2, Foxp1, and Foxa1 are other members of the Fox family that show regulated ... Cited by 1 - Related articles - All 3 versions
AVW Nunn, JD Bell, GW Guy - Nutrition & Metabolism, 2009 - biomedcentral.com Address: 1Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Hammersmith
Hospital, Imperial College London, Du Cane Road, London, W12 OHS, UK and 2GW
pharmaceuticals, Porton Down, Dorset, UK Email: Alistair VW Nunn* - alistair.nunn@ ... Cited by 1 - Related articles - View as HTML - All 7 versions
JJ Tomlinson, A Boudreau, D Wu, HA Salem, A … - Molecular …, 2009 - Endocrine Soc Glucocorticoids promote adipogenesis in vivo and when present in excess promote the development
of visceral obesity and insulin resistance, hallmarks of the metabolic syndrome (1, 2). Thus, patients
with Cushing's syndrome, in which adrenal glucocorticoid production is elevated ...
- ►wdc-jp.com [PDF] Y Johmura, K Watanabe, K Kishimoto, T Ueda, S … - … & Pharmaceutical Bulletin, 2009 - J-STAGE Obesity is a major risk factor for type 2 diabetes, hyper- tension, hyperlipidemia, and also
arteriosclerosis.1) The inci- dence of obesity has been increasing worldwide, and new ap- proaches
to treatment are desired. The increase in adipose tissue mass in obese individuals is ... Related articles - All 4 versions
M Artal-Sanz, N Tavernarakis - Nature, 2009 - imbb.forth.gr Marked alterations in cellular energy metabolism are a universal hallmark of the ageing
process1. The biogenesis and function of mitochondria, the energy-generating organelles in
eukaryotic cells, are primary longevity determinants. Genetic or pharmacological ... Related articles - View as HTML - All 5 versions
E Rosen, J Eguchi, Z Xu - Expert Opin. Ther. Targets, 2009 - informahealthcare.com The global burden of metabolic disease demands that we develop new therapeutic
strategies. Many of these approaches may center on manipulating the behavior of
adipocytes, which contribute directly and indirectly to a host of disease processes ... Related articles - All 6 versions
