JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a
metabolic disorder initiated by insulin resistance, it has recently become
apparent that an impairment in insulin secretion contributes to its mani- ... Cited by 31 - Related articles - BL Direct - All 3 versions
T Jin - Diabetologia, 2008 - Springer Abstract The WNT signalling pathway is involved in many physiological and
pathophysiological activities. WNT ligands bind to Frizzled receptors and
co-receptors (LDL receptor-related protein 5/6), triggering a cascade of ... Cited by 12 - Related articles - All 3 versions
- ►cnam.fr [PDF] JF Gautier, SP Choukem, J Girard - Diabetes and Metabolism, 2008 - Elsevier Incretin hormones are defined as intestinal hormones released in response to
nutrient ingestion, which potentiate the glucose-induced insulin response. In
humans, the incretin effect is mainly caused by two peptide hormones, ... Cited by 9 - Related articles - All 6 versions
HJ Welters, RN Kulkarni - Trends in Endocrinology & Metabolism, 2008 - Elsevier Interest in the importance of Wnt signaling in diabetes has risen after
identification of the transcription factor TCF7L2, a component of this pathway,
as a strong risk factor for type 2 diabetes. Here, we review emerging new ... Cited by 8 - Related articles - All 2 versions
P Osmark, O Hansson, A Jonsson, T Rönn, L … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Intronic variation in the TCF7L2 gene exhibits the
strongest association to type 2 diabetes observed to date, but the mechanism
whereby this genetic variation translates into altered biological function ... Cited by 6 - Related articles - All 2 versions
- ►endojournals.org T Jin, L Liu - Molecular Endocrinology, 2008 - Endocrine Soc Since the relationship between TCF7L2 (also known as TCF-4) polymorphisms and
type 2 diabetes mellitus was identified in 2006, extensive genome-wide
association examinations in different ethnic groups have further confirmed ... Cited by 6 - Related articles - All 4 versions
B Friedrich, P Weyrich, A Stančáková, J … - PLoS ONE, 2008 - pubmedcentral.nih.gov Copyright Friedrich et al. This is an open-access article distributed under the
terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original ... Cited by 4 - Related articles - All 6 versions
AL Gloyn, MI McCarthy - Diabetic Medicine, 2008 - interscience.wiley.com The identification and functional characterisation of genetic variants that
either cause or predispose to diabetes is a major focus of biomedical research.
The molecular basis is now known for the majority of monogenic forms of ... Cited by 3 - Related articles - All 3 versions
- ►endocrinology-journals.org T Jin - Journal of Endocrinology, 2008 - Soc Endocrinology The proglucagon gene (gcg) encodes a number of peptide hormones that are of
cell-type specifically expressed in the pancreatic islets, the distal ileum and
the large intestine, as well as certain brain neuronal cells. These ... Cited by 3 - Related articles - All 8 versions
- ►endocrinology-journals.org HJ Welters, A Oknianska, KS Erdmann, GU … - Journal of Endocrinology, 2008 - Soc Endocrinology In pancreatic β-cells, increased expression of the MODY5 gene product, HNF1β,
leads to enhanced rates of apoptosis and altered regulation of the cell cycle,
suggesting that control of HNF1β expression may be important for the ... Cited by 2 - Related articles - BL Direct - All 5 versions
