F Peng, D Wu, B Gao, AJ Ingram, B Zhang, K … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Glucose led to RhoA and downstream Rho-kinase activation. Mannitol was
without effect. Activity of the transcription factor AP-1, increased in diabetic
MCs and kidneys, is important in the profibrotic effects of glucose, and ... Cited by 10 - Related articles - All 4 versions
R Arita, Y Hata, S Nakao, T Kita, M Miura, S … - Diabetes, 2009 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Localization of RhoA/ROCK and Rho activity were
examined in retinal tissues of rats. Impact of intravitreal fasudil
administration on retinal endothelial nitric oxide synthase (eNOS) and ... Cited by 7 - Related articles - All 4 versions
D Barit, ME Cooper - Journal of Hypertension, 2008 - journals.lww.com Diabetic nephropathy, the major cause of end-stage renal disease in the world
occurs as a result of both metabolic and haemodynamic insults, thus emphasizing
the importance of optimizing glycaemic and blood pressure control in ... Cited by 2 - Related articles - All 5 versions
- ►diabetesjournals.org LA Bach - Diabetes, 2008 - Am Diabetes Assoc RhoA/ROCK has a number of functions in the kidney. RhoA/ROCK enhances Ca 2+
-dependent vascular smooth muscle contraction, thereby modulating tone (2–4).
The potent vasoconstrictor angiotensin II (AngII) activates ROCK in smooth ... Cited by 2 - Related articles - BL Direct - All 3 versions
A Whaley-Connell, J Habibi, Y Wei, A … - American Journal of Physiology- Renal Physiology, 2009 - Am Physiological Soc Adam Whaley-Connell 1,3,6 , Javad Habibi 1,3,6 , Yongzhong Wei 1,3,6 , Alex
Gutweiler 1,3,6 , Jessica ... Jellison 1 , Charles E Wiedmeyer 4 , Carlos M
Ferrario 5 , James R Sowers 1,2,3,6 ... 1 University of Missouri-Columbia ... Cited by 1 - Related articles - All 4 versions
DH Lee, J Shi, NH Jeoung, MS Kim, JM … - Journal of Biological Chemistry, 2009 - ASBMB Insulin signaling is essential for normal glucose homeostasis. Rho-kinase (ROCK)
isoforms have been shown to participate in insulin signaling and glucose
metabolism in cultured cell lines. To investigate the physiological role of ... Related articles - All 3 versions
P Balakumar, MK Arora, J Reddy, MB Anand- … - Journal of Cardiovascular Pharmacology, 2009 - journals.lww.com Abstract: Diabetic nephropathy is a major cause of end-stage renal failure and
the mortality rate due to this disease is continuously progressing worldwide.
The multifaceted signalling mechanisms have been identified to be involved ... Related articles - All 5 versions
SY Goh, M Jasik, ME Cooper - Expert Opin. Emerging Drugs, 2008 - informahealthcare.com Background: Nephropathy is a major cause of morbidity and mortality in diabetic
patients. Current treatments include optimization of glycemic and blood pressure
control, but more innovative strategies are needed for the prevention and ... Related articles - All 6 versions
- ►southalabama.edu [PDF] MB Zimering, Z Pan - Journal of Clinical Endocrinology & Metabolism, 2009 - Endocrine Soc Context: Macular edema contributes to visual impairment, and albuminuria is
associated with increased cardiovascular mortality in adults with type 2
diabetes mellitus. These microvascular complications result from increased ... Related articles - All 7 versions
M Naito, A Shenoy, I Aoyama, JS … - Am J Nephrol, 2009 - content.karger.com Background: Hyperglycemia may potentiate the adverse renal effects of
angiotensin II (AII). In the kidney, the major target of AII action is the
glomerular mesangial cell, where its hemodynamic and proinflammatory action ... Related articles - All 4 versions
