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Scholar Results 1 - 10 of 10 citing Aly: Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus.... (0.07 sec) 

Extreme genetic risk for type 1A diabetes in the post-genome era

- nih.gov
EE Baschal, GS Eisenbarth - Journal of autoimmunity, 2008 - Elsevier
A series of genes and loci influencing the genetic risk of type 1A
(immune-mediated) diabetes are now well characterized. These include genes of
the major histocompatibility complex (MHC), polymorphisms 5′ of the ...
Cited by 13 - Related articles - All 3 versions

The genetic basis for type 1 diabetes.


KL Mehers, KM Gillespie - British medical bulletin, 2008 - ncbi.nlm.nih.gov
BACKGROUND: Type 1 diabetes (T1D) is characterized by autoimmune destruction of
insulin-producing beta-cells in the pancreas resulting from the action of
environmental factors on genetically predisposed individuals. The ...
Cited by 2 - Related articles - All 4 versions

Confirmation of HLA class II independent type 1 diabetes associations in the major …


JM Howson, NM Walker, D Clayton, JA Todd … - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com
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Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma-Associated …


KP Tse, WH Su, KP Chang, NM Tsang, CJ Yu, … - The American Journal of Human Genetics, 2009 - Elsevier
Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated
with genetic factors and Epstein-Barr virus infection. To identify the common
genetic variants linked to NPC susceptibility, we conducted a genome-wide ...
Related articles - All 2 versions

[PDF] Genetics of type 1 diabetes: recent progress and future perspectives


AM Wägner, JC Wiebe - avances en, 2009 - sediabetes.org
Av Diabetol. 2009; 25: 175-86 Diabetología avances en 175 Abstract Type 1
diabetes (T1D) is a chronic immune-mediated disease, charac- terised by a
selective loss of insulin-producing ß-cells in the pancreatic islets. ...
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Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D …


I Santin, A Castellanos-Rubio, AM Aransay, G … - Genes and Immunity, 2009 - nature.com
The objective of this study was to identify additional diabetes susceptibility
markers in the MHC that could be responsible for the differential
diabetogenicity of different HLA-DR3 CEHs. High-resolution SNP genotyping ...
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Defining multiple common “completely” conserved major histocompatibility complex SNP …


EE Baschal, TA Aly, JM Jasinski, AK Steck, JA … - Clinical Immunology, 2009 - Elsevier
The availability of both HLA data and genotypes for thousands of SNPs across the
major histocompatibility complex (MHC) in 1240 complete families of the Type 1
Diabetes Genetics Consortium allowed us to analyze the occurrence and ...
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Reproducible association with type 1 diabetes in the extended class I region of the major …


MK Viken, A Blomhoff, M Olsson, HE Akselsen … - Genes and Immunity, 2009 - nature.com
The high-risk human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 alleles cannot
explain the entire type 1 diabetes (T1D) association observed within the
extended major histocompatibility complex. We have earlier identified an ...
Related articles - All 3 versions

The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than …


EE Baschal, TA Aly, JM Jasinski, AK Steck, KN … - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com
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display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ...
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High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus …


LF Barcellos, SL May, PP Ramsay, HL Quach, … - PLoS Genet, 2009 - dx.plos.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by
autoantibody production and involvement of multiple organ systems. Although the
cause of SLE remains unknown, several lines of evidence underscore the ...
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