H Unoki, A Takahashi, T Kawaguchi, K Hara, M … - Nature Genetics, 2008 - nature.com We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals
with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated
channel, KQT-like subfamily, member 1) to be a strong candidate for conferring ... Cited by 51 - Related articles - All 3 versions
- ►diabetesjournals.org [PDF] RM Freathy, NJ Timpson, DA Lawlor, A Pouta, Y Ben- … - Diabetes, 2008 - Am Diabetes Assoc Page 1. Common variation in the FTO gene alters diabetes-related metabolic traits
to the extent expected, given its effect on BMI Rachel M Freathy, PhD 1 *, Nicholas
J Timpson, PhD 2,3 *, Debbie A Lawlor, PhD 3,4 , Anneli ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org MI McCarthy, JN Hirschhorn - Human Molecular Genetics, 2008 - Oxford Univ Press Genome-wide association studies have successfully identified numerous loci at which common
variants influence disease risk or quantitative traits. Despite these successes, the variants identified
by these studies have generally explained only a small fraction of the heritable ... Cited by 30 - Related articles - All 3 versions
- ►nih.gov K Hotta, Y Nakata, T Matsuo, S Kamohara, K Kotani … - Journal of human …, 2008 - Springer Abstract Variations in the fat-mass and obesity-associated gene (FTO) are associated with the
obesity phenotype in many Caucasian populations. This association with the obesity phenotype
is not clear in the Japanese. To investigate the relationship between the FTO gene and ... Cited by 29 - Related articles - BL Direct - All 7 versions
Y Wu, H Li, RJF Loos, Z Yu, X Ye, L Chen, A Pan, FB … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations between type 2 diabetes and variants near CDKAL1
(odds ratio 1.49 [95% CI 1.27–1.75]; P = 8.91 × 10 −7 ) and CDKN2A/B (1.31 [1.12–1.54]; P =
1.0 × 10 −3 ). We observed significant association of SNPs in IGF2BP2 (1.17 [1.03–1.32]; ... Cited by 28 - Related articles - All 5 versions
TW Boesgaard, J Žilinskaitė, M Vänttinen, M Laakso, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis A recent genome-wide association study identified the SLC30A8 rs13266634
polymorphism encoding an Arg325Trp polymorphism in the zinc transporter protein member
8 (ZnT-8) to be associated with type 2 diabetes. Here, ... Keywords Beta cell dysfunction . ... Cited by 20 - Related articles - BL Direct - All 3 versions
S Cauchi, D Meyre, E Durand, C Proença, M Marre, S … - PloS one, 2008 - pubmedcentral.nih.gov In the same French population analyzed in our previous GWA study (3,295 T2D and 3,595
NGT), strong associations with T2D were found for CDKAL1 (OR rs7756992 =
1.30[1.19–1.42], P = 2.3×10 −9 ), CDKN2A/2B (OR rs10811661 = 0.74[0.66–0.82], P = ... Cited by 21 - Related articles - All 7 versions
- ►diabetesjournals.org YC Chang, PH Liu, WJ Lee, TJ Chang, YD Jiang, HY Li … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity
(P = 7.0 x 10 –4 ) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity
was 2.60 (95% CI 1.24–5.46) (P = 0.011) for the AA genotype and 1.32 (1.05–1.66) (P = ... Cited by 21 - Related articles - All 4 versions
- ►endojournals.org Y Horikawa, K Miyake, K Yasuda, M Enya, Y … - Journal of Clinical …, 2008 - Endocrine Soc Results: A total of 15 SNPs were genotyped. Eight SNPs in five loci were found to be associated
with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI)
1.05–1.27); P = 4.5 x 10 –3 ] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14–1.40); P = ... Cited by 20 - Related articles - All 3 versions
DK Sanghera, L Ortega, S Han, J Singh, SK … - BMC Medical …, 2008 - biomedcentral.com Recent genome-wide association (GWA) studies have identified several unsuspected genes
associated with type 2 diabetes (T2D) with previously unknown functions. In this
investigation, we have examined the role of 9 most significant SNPs reported in GWA ... Cited by 22 - Related articles - Cached - All 10 versions
