SF Yan, R Ramasamy, AM Schmidt - Nature clinical practice. …, 2008 - ncbi.nlm.nih.gov Many important biochemical mechanisms are activated in the presence of high levels of
glucose, which occur in diabetes. Elevated levels of glucose accelerate the formation of advanced
glycation end-products (AGEs). Via their chief signaling receptor-the AGE-specific ... Cited by 27 - Related articles - BL Direct - All 3 versions
K Sugimoto, M Yasujima, S Yagihashi - Current pharmaceutical …, 2008 - ingentaconnect.com Abstract: Diabetic neuropathy is the commonest form of peripheral neuropathy in the developed
countries of the world. In diabetic pa- tients, the presence of peripheral neuropathy increases
their risks for developing foot ulceration and subsequent necrosis that necessitates lower ... Cited by 22 - Related articles - BL Direct - All 3 versions
C Figueroa-Romero, M Sadidi, EL Feldman - Reviews in Endocrine & …, 2008 - Springer Abstract Diabetic neuropathy is the most common com- plication of diabetes, affecting 50% of
diabetic patients. Currently, the only treatment for diabetic neuropathy is glucose control and
careful foot care. In this review, we discuss the idea that excess glucose overloads the ... Cited by 11 - Related articles - All 2 versions
- ►prsjournal.com DW Zochodne - Current opinion in neurology, 2008 - journals.lww.com Recent findings: Diabetic neuropathies are common and rising in prevalence with the global
burden of type 2 diabetes. Polyneuropathy is also emerging as a complication of impaired glucose
tolerance, without frank diabetes. Ideas about the pathogenesis of diabetic ... Cited by 9 - Related articles - All 9 versions
V Brussee, GF Guo, YY Dong, C Cheng, JA Martinez, D … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—ZDF rats developed slowing of motor sciatic-tibial and sensory sciatic digital conduction
velocity and selective mechanical allodynia with preserved thermal algesia. Diabetic sural
axons, preserved in number, developed atrophy, but there was loss of large-calibre ... Cited by 5 - Related articles - All 3 versions
SF Yan, R Ramasamy, AM Schmidt - Journal of Molecular Medicine, 2009 - Springer Abstract The actors in the pathogenesis of diabetes and its complications are many and
multifaceted. The effects of elevated levels of glucose are myriad; among these is the generation
of advanced glycation end products (AGEs), the products of nonenzymatic glycoxidation ... Cited by 5 - Related articles - All 3 versions
SF Yan, SD Yan, R Ramasamy, AM Schmidt - Annals of Medicine, 2009 - informahealthcare.com The multiligand receptor RAGE (receptor for advanced glycation end-products) is emerging as
a central mediator in the immune/inflammatory response. Epidemiological evidence accruing
in the human suggests upregulation of RAGE's ligands (AGEs, S100/calgranulins, high ... Cited by 3 - Related articles - All 3 versions
C Yu, S Rouen, RT Dobrowsky - Glia, 2008 - pubmedcentral.nih.gov Neuregulins (NRGs) are growth factors which bind to Erb receptor tyrosine kinases that localize
to Schwann cells (SCs). Although NRGs can promote cell survival, mitogenesis, and myelination
in undifferentiated SCs, they also induce demyelination of myelinated co-cultures of SCs ... Cited by 4 - Related articles - BL Direct - All 4 versions
IG Obrosova - BBA-Molecular Basis of Disease, 2009 - Elsevier Diabetes-induced damage to peripheral nerve culminates in development of peripheral diabetic
neuropathy (PDN), one of the most devastating complications of diabetes mellitus and a leading
cause of foot amputation. The pathogenesis of PDN occurs as a consequence of complex ... Cited by 1 - Related articles - All 2 versions
I VARENIUK, PAL PACHER, IA PAVLOV, … - … journal of molecular …, 2009 - pubmedcentral.nih.gov Evidence for the important role of the potent oxidant peroxynitrite in peripheral diabetic neuropathy
and neuropathic pain is emerging. This study evaluated the contribution of neuronal nitric oxide
synthase (nNOS) to diabetes-induced nitrosative stress in peripheral nerve and dorsal ... Cited by 1 - Related articles - All 4 versions
