- ►cell.com H Ounissi-Benkalha, C Polychronakos - Trends in Molecular Medicine, 2008 - Elsevier Susceptibility to type 1 diabetes (T1D) is determined by complex interactions between several
genetic loci and environmental factors. Alleles at the human leukocyte antigen (HLA) locus explain
up to 50% of the familial clustering of T1D, and the remainder is contributed to by multiple ... Cited by 13 - Related articles - All 4 versions
- ►nih.gov EE Baschal, GS Eisenbarth - Journal of autoimmunity, 2008 - Elsevier A series of genes and loci influencing the genetic risk of type 1A (immune-mediated) diabetes
are now well characterized. These include genes of the major histocompatibility complex
(MHC), polymorphisms 5′ of the insulin gene, and PTPN22, as well as more recently ... Cited by 13 - Related articles - All 3 versions
DB Rainbow, L Esposito, SK Howlett, KM … - Biochemical Society …, 2008 - pubmedcentral.nih.gov The MHC region remains the major genetic determinant causing T1D in humans and NOD mice
[1, 2] and the identification of non-MHC genes contributing T1D susceptibility has made significant
progress. Of particular note, in 2007 it was demonstrated unequivocally that ... Cited by 6 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org V Butty, C Campbell, D Mathis, C Benoist - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The unfolding of type 1 diabetes involves a number of steps: defective immunological
tolerance, priming of anti-islet autoimmunity, and destruction of insulin-producing β-cells. A number
of genetic loci contribute to susceptibility to type 1 diabetes, but it is unclear which stages ... Cited by 4 - Related articles - All 5 versions
S Caillat-Zucman - Tissue Antigens, 2009 - interscience.wiley.com The association of human leukocyte antigen (HLA) molecules with many autoimmune diseases
has been long known. Yet, the molecular basis for these associations remains unclear for most
of these diseases because of the lack of identification of a primary target autoantigen or ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org P Concannon, WM Chen, C Julier, G Morahan, B … - Diabetes, 2009 - Am Diabetes Assoc RESULTS Significant evidence of linkage to type 1 diabetes was confirmed at the HLA region
on chromosome 6p21.3 (logarithm of odds [LOD] = 213.2). There was further evidence of linkage
to type 1 diabetes on 6q that could not be accounted for by the major linkage signal at the ... Cited by 3 - Related articles - All 4 versions
M Pietropaolo, JM Surhigh, PW Nelson, GS Eisenbarth - Diabetes, 2008 - Am Diabetes Assoc For nonimmunologists, a daunting and rapidly evolving immunologic vocabulary, our incomplete
understanding of both normal and abnormal immune function, and multiple interrelated complex
immune cellular pathways can be a barrier to using basic immunology to understand and ... Cited by 4 - Related articles - All 9 versions
GA Heap, DA van Heel - Human Molecular Genetics, 2009 - Oxford Univ Press Chronic inflammatory diseases have been at the forefront of the new genome-wide association
study era. Conditions such as coeliac disease, type 1 diabetes, Crohn's disease and ulcerative
colitis have all benefited with multiple loci identified and replicated for each condition. As ... Cited by 2 - Related articles - All 3 versions
M Amills, O Ramírez, A Tomàs, G Obexer-Ruff, O … - Genes and Immunity, 2008 - nature.com Major histocompatibility complex class II DQA and DQB genes have been shown to be under
positive selection in certain mammalian species but not in others, fuelling a debate about how
their polymorphism has evolved. In this study, we have analysed whether polymorphism ... Cited by 2 - Related articles - All 3 versions
SHS Pearce, TR Merriman - Endocrinology and Metabolism Clinics of North …, 2009 - Elsevier The search for the susceptibility alleles for the complex genetic conditions of type 1 diabetes
and autoimmune thyroid diseases has gained momentum in recent years. Studies have revealed
several novel disease susceptibility alleles of relevance to both conditions, which brings ... Cited by 2 - Related articles - All 11 versions
