KJ Chang-Chen, R Mullur, E Bernal-Mizrachi - Reviews in Endocrine & …, 2008 - Springer Abstract Type 2 diabetes mellitus is a complex disease characterized by b-cell failure in the setting
of insulin resistance. In early stages of the disease, pancreatic b-cells adapt to insulin resistance
by increasing mass and function. As nutrient excess persists, hyperglycemia and elevated ... Cited by 12 - Related articles - All 2 versions
- ►diabetesjournals.org MC Akerfeldt, J Howes, JY Chan, VA Stevens, N … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced by increased
phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation factor (EIF)2α, and Jun NH
2 -terminal kinase (JNK) and increased expression of activating transcription factor ... Cited by 9 - Related articles - All 3 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell …, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of elevated
glucose, and fatty acid levels on pancreatic beta-cell function and survival. Significant progress
has been made in recent years towards a better understanding of the cellular and ... Cited by 9 - Related articles - BL Direct - All 4 versions
E Bachar, Y Ariav, M Ketzinel-Gilad, E Cerasi, N … - PLoS One, 2009 - pubmedcentral.nih.gov We found that glucose amplifies palmitate-induced ER stress by increasing IRE1α protein levels
and activating the JNK pathway, leading to increased β-cell apoptosis. Moreover, glucose increased
mTORC1 activity and its inhibition by rapamycin decreased β-cell apoptosis under ... Cited by 6 - Related articles - All 5 versions
- ►jbc.org J Smith, X Su, R El-Maghrabi, PD Stahl, NA … - Journal of Biological …, 2008 - ASBMB FAT/CD36 is a membrane scavenger receptor that facilitates long chain fatty acid uptake by
muscle. Acute increases in membrane CD36 and fatty acid uptake have been reported in response
to insulin and contraction. In this study we have explored protein ubiquitination as one ... Cited by 3 - Related articles - All 5 versions
MM Sachdeva, DA Stoffers - Molecular Endocrinology, 2009 - Endocrine Soc Type 2 diabetes results from pancreatic ß-cell failure in the setting of insulin resistance. This
model of disease progression has received recent support from the results of genome-wide association
studies that identify genes potentially regulating ß-cell growth and function as type 2 ... Cited by 2 - Related articles - All 3 versions
M Malaguarnera, M Di Rosa, F Nicoletti, L … - Journal of Molecular …, 2009 - Springer Abstract Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic-related disorder
characterized by fatty infiltration of the liver in the absence of alcohol consump- tion. NAFLD
ranges from simple steatosis to non-alcoholic steatohepatitis (NASH), which might ... Cited by 2 - Related articles - All 2 versions
EONFA UPTAKE - THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2008 - ASBMB FAT/CD36 is a membrane scavenger receptor that facilitates long chain fatty acid uptake by
muscle. Acute increases in mem- brane CD36 and fatty acid uptake have been reported in response
to insulin and contraction. In this study we have explored protein ubiquitination as one ... Related articles
X Zhang, W Yong, J Lv, Y Zhu, J Zhang, F Chen, R … - Endocrinology, 2009 - Endocrine Soc Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and
its activity can be increased by dexamethasone (DEX) in several cell types. However, the role
of FoxO1 in DEX-induced pancreatic β-cell dysfunction has not been fully understood. ... Related articles - All 3 versions
