- ►fasebj.org J Chen, ST Hui, FM Couto, IN Mungrue, DB Davis, AD … - The FASEB Journal, 2008 - FASEB Pancreatic beta-cell loss through apoptosis represents a key factor in the pathogenesis of
diabetes; however, no effective approaches to block this process and preserve endogenous
beta-cell mass are currently available. To study the role of thioredoxin-interacting protein ( ... Cited by 11 - Related articles - All 5 versions
- ►diabetesjournals.org JA Corbett - Diabetes, 2008 - Am Diabetes Assoc The oxidation of glucose is required for the secretion of insulin by pancreatic β-cells. The product
of this oxidation, ATP, stimulates the closure of potassium channels and calcium-dependent
exocytosis of insulin. This system is beautifully regulated such that the precise amount of ... Cited by 5 - Related articles - BL Direct - All 3 versions
M Bensellam, L Van Lommel, L Overbergh, FC Schuit, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Survival and function of insulin-secreting pancreatic beta cells are
markedly altered by changes in nutrient availability. In vitro, culture in 10 rather than 2
mmol/l glucose improves rodent beta cell survival and function, whereas glucose ... Cited by 1 - Related articles - All 3 versions
A Shalev - Biochemical Society Transactions, 2008 - biochemsoctrans.org Glucotoxicity plays a major role in pancreatic β-cell apoptosis and diabetes progression, but
the factors involved have remained largely unknown. Our recent studies have identified TXNIP
(thioredoxin-interacting protein) as a novel pro-apoptotic β-cell factor that is induced by ... Cited by 1 - Related articles - Cached - All 5 versions
S Oka, E Yoshihara, A Bizen-Abe, W Liu, M Watanabe, … - Endocrinology, 2009 - Endocrine Soc The feeding-fasting nutritional transition triggers a dynamic change in metabolic pathways and
is a model for understanding how these pathways are mutually organized. The targeted disruption
of the thioredoxin binding protein-2 (TBP-2)/thioredoxin-interacting protein ... Cited by 1 - Related articles - All 2 versions
HE Thomas, MD McKenzie, E Angstetra, PD Campbell, … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss
of islets after trans- plantation. In type 1 diabetes, beta cells are destroyed by immunological
mechanisms. In type 2 diabetes abnormal levels of metabolic factors contribute to beta ... Cited by 2 - Related articles - All 2 versions
AA Anderson, J Helmering, T Juan, CM Li, J … - …, 2009 - pubmedcentral.nih.gov C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared
with C57BL6/J (B6) mice, as observed by the presence of the leptin receptor (Lepr) allele, Lepr
db/db . Furthermore, DBA2/J (DBA) mice are also susceptible to β-cell failure and share ... Cited by 2 - Related articles - All 5 versions
- ►endojournals.org [PDF] S Oka, E Yoshihara, A Bizen-Abe, W Liu, M Watanabe, … - Endocrinology, 2008 - Endocrine Soc Page 1. 1 Title Thioredoxin Binding Protein-2 (TBP-2)/Txnip is a Critical Regulator of Insulin
Secretion and PPAR Function. Short title TBP-2 regulates PPAR in fasting response. Authors
Shin-ichi Oka, Eiji Yoshihara,Akiko Bizen-Abe, Wenrui Liu, Mutsumi Watanabe, Junji ... Cited by 1 - Related articles
H Cha-Molstad, G Saxena, J Chen, A Shalev - Journal of Biological Chemistry, 2009 - ASBMB Recently, we identified Txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta
cell death and discovered that lack of Txnip protects against streptozotocin- and obesity-induced
diabetes by preventing beta cell apoptosis and preserving endogenous beta cell mass. ... Cited by 1 - Related articles - All 2 versions
W Qi, X Chen, J Holian, CYR Tan, DJ Kelly, CA … - American Journal of …, 2009 - ASIP We demonstrated recently that thioredoxin-interact- ing protein (Txnip) and the transcription factor
Krüp- pel-like factor 6 (KLF6) were up-regulated in both in vivo and in vitro models of diabetic
nephropathy, thus promoting renal injury. Conversely, peroxisome proliferator-activated ... Related articles - All 2 versions
