E Bachar, Y Ariav, M Ketzinel-Gilad, E Cerasi, … - PLoS One, 2009 - pubmedcentral.nih.gov We found that glucose amplifies palmitate-induced ER stress by increasing IRE1α
protein levels and activating the JNK pathway, leading to increased β-cell
apoptosis. Moreover, glucose increased mTORC1 activity and its inhibition ... Cited by 6 - Related articles - All 5 versions
S Boura-Halfon, Y Zick - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Insulin signaling at target tissues is essential for growth and development and
for normal homeostasis of glucose, fat, and protein metabolism. Control over
this process is therefore tightly regulated. It can be achieved by a ... Cited by 6 - Related articles - All 3 versions
G Leibowitz, E Cerasi, M Ketzinel-Gilad - Diabetes, Obesity and Metabolism, 2008 - interscience.wiley.com Mammalian target of rapamycin (mTOR) is an important nutrient sensor that plays
a critical role in cellular metabolism, growth, proliferation and apoptosis and
in the cellular response to oxidative stress. In addition, mTOR–raptor ... Cited by 4 - Related articles - All 3 versions
- ►unibas.ch [PDF] P Polak, MN Hall - Current Opinion in Cell Biology, 2009 - Elsevier This review summarizes the major findings in the mTOR field within the past two
years. But, first we briefly describe the status of the mTOR signaling network
as it was two years ago. Two years ago, it was known that mTORC1 is ... Cited by 6 - Related articles - All 3 versions
C Hinault, J Hu, BF Maier, RG Mirmira, RN … - Diabetes Obes Metab, 2008 - interscience.wiley.com One of the major challenges for developmental biologists and investigators in
the field of diabetes over the last few decades has been to dissect the origin
of pancreatic endocrine cells and to accurately understand the mechanisms ... Cited by 3 - Related articles - All 2 versions
K Sankhala, A Mita, K Kelly, D Mahalingam, F … - Targeted Oncology, 2009 - Springer Page 1. REVIEW The emerging safety profile of mTOR inhibitors, a novel class of
anticancer agents Kamalesh Sankhala & Alain Mita & Kevin Kelly & ... Cited by 4 - Related articles - All 2 versions
M Pavlakis, AS Goldfarb-Rumyantzev - Journal of the American Society of Nephrology, 2008 - Am Soc Nephrol New-onset diabetes is a common complication of renal transplantation. The
appearance of this form of diabetes is associated with worsening cardiovascular
risk and loss of renal allograft function. 1–3 The most important ... Cited by 2 - Related articles - All 4 versions
MM Sachdeva, DA Stoffers - Molecular Endocrinology, 2009 - Endocrine Soc Type 2 diabetes results from pancreatic ß-cell failure in the setting of
insulin resistance. This model of disease progression has received recent
support from the results of genome-wide association studies that identify ... Cited by 2 - Related articles - All 3 versions
C Kargar, A Ktorza - Diabetes, Obesity and Metabolism, 2008 - interscience.wiley.com The ability of pancreatic β-cell mass to vary according to insulin requirements
is an important component of optimal long-term control of glucose homeostasis.
It is generally assumed that alteration of this property largely ... Cited by 1 - Related articles - All 2 versions
MC Crouthamel, JA Kahana, S Korenchuk, SY … - Clinical Cancer Research, 2009 - AACR Purpose: Insulin-like growth factor-I receptor and phosphoinositide
3-kinase/AKT/mammalian target of rapamycin pathways are among the most active
areas of drug discovery in cancer research. However, due to their integral ... Cited by 1 - Related articles - All 3 versions
