- ►diabetesjournals.org ZV Wang, J Mu, TD Schraw, L Gautron, JK Elmquist, BB … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Islet transplantations have been performed clinically, but their practical applications
are limited. An extensive effort has been made toward the identification of pancreatic β-cell stem
cells that has yielded many insights to date, yet targeted reconstitution of β-cell mass ... Cited by 4 - Related articles - All 4 versions
- ►physiology.org S Pascal, Y Guiot, S Pelengaris, M Khan, … - American Journal of …, 2008 - Am Physiological Soc Alteration of pancreatic β-cell survival and Preproinsulin gene expression by prolonged hyperglycemia
may result from increased c-MYC expression. However, it is unclear whether c-MYC effects on
β-cell function are compatible with its proposed role in glucotoxicity. We therefore tested ... Cited by 3 - Related articles - All 3 versions
M von Herrath, GT Nepom - Nature Immunology, 2009 - nature.com Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta
cells are damaged and destroyed. Animal models have served a prominent function in the development
of the present ideas of pathogenesis and approaches to therapy. This commentary ... Cited by 4 - Related articles - All 3 versions
T Jin - Medical hypotheses, 2008 - Elsevier Type II diabetes mellitus (T2D) develops as the consequence of relative insulin insufficiency.
The onset of T2D is characterized by insulin resistance, and in most cases, with hyperinsulinemia
for compensation. Extensive basic and clinical examinations have identified a large ... Cited by 2 - Related articles - All 33 versions
MM Sachdeva, DA Stoffers - Molecular Endocrinology, 2009 - Endocrine Soc Type 2 diabetes results from pancreatic ß-cell failure in the setting of insulin resistance. This
model of disease progression has received recent support from the results of genome-wide association
studies that identify genes potentially regulating ß-cell growth and function as type 2 ... Cited by 2 - Related articles - All 3 versions
A Khalaileh, T Gonen-Gross, J … - Diabetes, Obesity …, 2008 - interscience.wiley.com Recent studies have revealed a surprising plasticity of pancreatic β-cell mass. β-cell mass is
now recognized to increase and decrease in response to physiological demand, for example
during pregnancy and in insulin-resistant states. Moreover, we and others have shown ... Cited by 1 - Related articles - All 2 versions
S Efrat - The Review of Diabetic Studies: RDS, 2008 - pubmedcentral.nih.gov Ex-vivo generation of human insulin-producing cells is considered a promising approach to providing
an abundant source of cells for beta-cell replacement therapy in diabetes. Expansion of adult
beta-cells from the limited number of islet donors is an attractive prospect. However, while ... Cited by 1 - Related articles - All 3 versions
HA Russ, P Ravassard, J Kerr-Conte, F Pattou, S Efrat - 2009 - pubmedcentral.nih.gov In-vitro expansion of functional beta cells from adult human islets is an attractive approach for
generating an abundant source of cells for beta-cell replacement therapy of diabetes. Using
genetic cell-lineage tracing we have recently shown that beta cells cultured from adult ... Related articles - All 3 versions
DA Cano, M Hebrok - Gastroenterology, 2008 - theclinics.com No abstract is available. To read the body of this article, please view the Full Text online. ... Corresponding
Author Information Address requests for reprints to: Matthias Hebrok, Diabetes Center, Department
of Medicine, University of California, San Francisco, CA 94143; Fax: (415) 564-5813. Related articles - Cached - All 21 versions
