S Schenk, M Saberi, JM Olefsky - The Journal of Clinical …, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of
a number of diseases, including type 2 diabetes. In this review, we discuss potential mechanisms
by which brief nutrient excess and obesity lead to insulin resistance and propose that ... Cited by 47 - Related articles - All 12 versions
- ►cnfindpark.cn JO Holloszy - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant offspring
of patients with diabetes have 30% less mitochondria in their skeletal muscles than age-matched
healthy controls. It has been hypothesized that this "deficiency" of mitochondria mediates ... Cited by 19 - Related articles - All 6 versions
- ►diabetesjournals.org IR Lanza, DK Short, KR Short, S Raghavakaimal, R … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Insulin sensitivity was measured by
hyperinsulinemic-euglycemic clamp and ATP production in mitochondria isolated from vastus
lateralis biopsies of 42 healthy sedentary and endurance-trained young (18–30 years ... Cited by 15 - Related articles - All 4 versions
N Turner, LK Heilbronn - Trends in Endocrinology & Metabolism, 2008 - Elsevier Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise factors
that lead to insulin resistance have not been elucidated fully, but there is a strong association
between insulin resistance and inappropriate lipid accumulation in insulin-target tissues. ... Cited by 13 - Related articles - All 5 versions
- ►cnfindpark.cn IR Lanza, KS Nair - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Aging has been reported to be accompanied by reduced mitochondrial function and insulin
sensitivity. Whether these deleterious effects result from chronological age or lifestyle-related
factors such as adiposity and physical inactivity remains debatable. The beneficial effects ... Cited by 9 - Related articles - All 6 versions
- ►cnfindpark.cn GP Holloway, A Bonen, LL Spriet - American Journal of Clinical …, 2009 - ajcn.cnfindpark.cn A reduction in fatty acid (FA) oxidation has been associated with lipid accumulation and insulin
resistance in skeletal muscle of obese individuals. Numerous reports suggest that the reduction
in FA oxidation may result from intrinsic mitochondrial defects, although little direct ... Cited by 7 - Related articles - All 6 versions
- ►nih.gov P Schrauwen, MKC Hesselink - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Mitochondrial dysfunction has been pos- tulated to underlie muscular
fat accumulation, leading to muscular insulin sensitivity and ultimately type 2 diabetes
mellitus. Here we re-interpret previously published data on [13C]acetate recovery in ... Cited by 3 - Related articles - All 8 versions
CM Frederiksen, K Højlund, L Hansen, EJ Oakeley, B … - Diabetologia, 2008 - Springer Methods Using cDNA microarray technology and global pathway analysis with the Gene Map
Annotator and Pathway Profiler (GenMapp 2.1) and Gene Set Enrichment Analysis (GSEA
2.0.1), we examined transcript levels in myotubes established from obese patients with ... Cited by 2 - Related articles - All 2 versions
- ►diabetesjournals.org C Snehalatha, A Yamuna, A Ramachandran - Diabetes care, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We studied 196 teenagers (94 boys, 102 girls) 12–18
years of age, selected from a cohort of 2,640 individuals from a cross-sectional school-based
survey in Chennai, India. For comparison, adiponectin and plasma insulin were ... Cited by 4 - Related articles - All 4 versions
IR Lanza, KS Nair - … Function, Part B: Mitochondrial Protein Kinases, …, 2009 - books.google.com > CHAPTER TWENTY Functional Assessment of Isolated Mitochondria In Vitro Ian R. Lanza
and K. Sreekumaran Nair Contents 1. Introduction 350 2. Mitochondrial Isolation Procedures
354 2.1. Tissue homogenization 355 2.2. Separation of mitochondria by differential ... Cited by 1 - Related articles - All 2 versions
