S Schenk, M Saberi, JM Olefsky - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Insulin resistance is a major metabolic feature of obesity and is a key factor
in the etiology of a number of diseases, including type 2 diabetes. In this
review, we discuss potential mechanisms by which brief nutrient excess and ... Cited by 47 - Related articles - All 12 versions
- ►nih.gov BK Surmi, AH Hasty - Future Lipidol., 2008 - Future Medicine It has long been known that adipose tissue in obesity is in a heightened state
of inflammation. Recently, our understanding of this has been transformed by the
knowledge that immune cells such as macrophages and T cells can infiltrate ... Cited by 5 - Related articles - All 5 versions
- ►nih.gov DA Gutierrez, MJ Puglisi, AH Hasty - Current diabetes reports, 2009 - Springer Obesity is associated with increased prevalence of metabolic disorders, such as
inflammation, insulin resistance, and dyslipidemia, which can predispose an
individual to develop diabetes and cardiovascu- lar disease. Adipose tissue ... Cited by 3 - Related articles - All 4 versions
K Oishi, K Miyazaki, D Uchida, N Ohkura, M … - Journal of Molecular and Cellular Cardiology, 2009 - Elsevier An increased level of obesity-induced plasma plasminogen activator inhibitor-1
(PAI-1) is considered a risk factor for cardiovascular disease. To determine
whether the circadian clock component PERIOD2 (PER2) is involved in the ... Cited by 3 - Related articles - All 23 versions
- ►physiology.org CS Nunemaker, M Chen, H Pei, SD Kimble, SR … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Inflammation is a key pathological process in the progression of atherosclerosis
and type 2 diabetes. 12/15-lipoxygenase (12-LO), an enzyme involved in fatty
acid metabolism, may contribute to inflammatory damage triggered by ... Cited by 1 - Related articles - All 3 versions
JG Neels, L Badeanlou, KD Hester, F Samad - Journal of Biological Chemistry, 2009 - ASBMB Obese adipose tissue (AT) is associated with chronic inflammation, and we
hypothesized that the keratinocyte-derived chemokine (KC), the mouse ortholog of
human interleukin-8, plays a role in obesity-mediated AT inflammation and ... Related articles - All 3 versions
D Patsouris, JG Neels, WQ Fan, PP Li, MTA … - The Journal of biological chemistry, 2009 - ASBMB The link between intra-abdominal adiposity and type II diabetes has been known
for decades and adipose tissue macrophage (ATM) associated inflammation has
recently been linked to insulin resistance. However, the mechanisms ... Related articles - All 3 versions
PJ Bilan, V Samokhvalov, A Koshkina, JD …, 2009 - Informa Pharma Science Obesity is associated with insulin resistance and increased risk for developing
type 2 diabetes. Enlarged adipocytes develop resistance to the anti-lipolytic
action of insulin. Elevated levels of fatty acids in the plasma and ... Related articles - All 5 versions
T Chiba, CY Han, T Vaisar, K Shimokado, A … - The Journal of Lipid Research, 2009 - ASBMB Adipose tissue secretes proteins like serum amyloid A (SAA), which plays
important roles in local and systemic inflammation. Circulating SAA levels
increase in obese humans, but the roles of adipose-derived SAA and ... Related articles - All 3 versions
