PJ Jost, S Grabow, D Gray, MD McKenzie, U Nachbur, … - BID - arapaho.nsuok.edu FAS (also called APO-1 and CD95) and its physiological ligand, FASL, regulate apoptosis of
unwanted or dangerous cells, func- tioning as a guardian against autoimmunity and cancer
develop- ment1–4. Distinct cell types differ in the mechanisms by which the 'death ... Cited by 4 - Related articles - View as HTML - All 5 versions
HE Thomas, MD McKenzie, E Angstetra, PD Campbell, … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss
of islets after trans- plantation. In type 1 diabetes, beta cells are destroyed by immunological
mechanisms. In type 2 diabetes abnormal levels of metabolic factors contribute to beta ... Cited by 2 - Related articles - All 2 versions
M Jak, M Jak, R Mous, EBM Remmerswaal, … - Leukemia & …, 2009 - informahealthcare.com Recently, it has been described that patients with chronic lymphocytic leukemia (CLL) have increased
numbers of regulatory T (T reg ) cells. In the present study, we analysed the mechanism behind
T reg cells expansion in CLL. Neither analysis of the T-cell receptor repertoire nor CD45 ... Cited by 1 - Related articles - All 4 versions
YS Lee, N Li, S Shin, HS Jun - The Journal of Virology, 2009 - jvi.highwire.org The D variant of encephalomyocarditis virus (EMC-D virus) causes diabetes in mice by destroying
pancreatic β cells. In mice infected with a low dose of EMC-D virus, macrophages play an important
role in β-cell destruction by producing soluble mediators such as interleukin-1β (IL-1β), ... Related articles - All 4 versions
G Szabadkai, MR Duchen - Apoptosis - Springer Abstract Mitochondrial dysfunction plays a role in the pathogenesis of a wide range of diseases
that involve dis- ordered cellular fuel metabolism and survival/death path- ways, including neurodegenerative
diseases, cancer and diabetes. Cytokine, virus recognition and cellular stress pathways ... Related articles - All 2 versions
HE Thomas, JA Trapani, TWH Kay - Cell Death & Differentiation, 2009 - nature.com Type 1 diabetes results from autoimmune destruction of pancreatic -cells by CD8 + T cells. The
requirement for CD8 + T cells implicates perforin and granzymes as effectors of tissue
destruction. Diabetogenic cytotoxic T cells kill -cells by the perforin/granzyme pathway in ...
GY Wang, QH Lv, Q Dong, RZ Xu, QH … - Journal of Asian Natural …, 2009 - ingentaconnect.com Berbamine, a natural compound from the plant Berberis amurensis, is a traditional Chinese medicine
mainly used in stimulating normal hematopoiesis in clinic. Our previous studies demonstrated
that berbamine has anti-leukemia activity. In this study, we investigated the anticancer ... Related articles - All 3 versions
ME Shawgo, SN Shelton, JD Robertson - Journal of Biological Chemistry, 2009 - ASBMB Activation of executioner caspases during receptor-mediated apoptosis in type II cells requires
the engagement of the mitochondrial apoptotic pathway. Although it is well established that recruitment
of mitochondria in this context involves the cleavage of Bid to truncated Bid (tBid), the ... Related articles - All 3 versions
K Bouzakri, P Ribaux, PA Halban - Journal of Biological Chemistry, 2009 - ASBMB Obesity and type 2 diabetes present partially overlapping phenotypes with systemic inflammation
as a common feature, raising the hypothesis that elevated cytokine levels may contribute to peripheral
insulin resistance as well as the decreased beta-cell functional mass observed in type 2 ... Related articles - All 3 versions
RS Hotchkiss, A Strasser, JE McDunn, PE … - New England Journal of …, 2009 - content.nejm.org Apoptosis is derived from an ancient Greek word that suggests "leaves falling from a tree." 22
, 23 , 24 In contrast to the swelling of the cell and its organelles that defines necrosis, the principal
morphologic feature of apoptosis is shrinkage of the cell and its nucleus (Figure 2 and ... Related articles - All 4 versions
