S Caillat-Zucman - Tissue Antigens, 2009 - interscience.wiley.com The association of human leukocyte antigen (HLA) molecules with many autoimmune diseases
has been long known. Yet, the molecular basis for these associations remains unclear for most
of these diseases because of the lack of identification of a primary target autoantigen or ... Cited by 5 - Related articles - All 4 versions
- ►diabetesjournals.org BO Roep - Diabetes, 2008 - Am Diabetes Assoc While differentiating T-cell autoreactivity against pancreatic islets between type 1 diabetic patients
and nondiabetic control subjects has, over time, proven to be a difficult task, the ultimate challenge
for cellular markers of this disease will involve the definition of immunological measures ... Cited by 5 - Related articles - BL Direct - All 3 versions
DL Faustman - New England Journal of Medicine, 2008 - content.nejm.org Type 1 diabetes mellitus is an autoimmune disease in which pathologic, autoreactive T cells
of the immune system attack the insulin-secreting pancreatic islets of Langerhans. Cytotoxic
T cells, which bear the CD8 protein on their membrane, kill islets, thereby leading to ... Cited by 2 - Related articles - All 5 versions
- ►diabetesjournals.org A Toma, T Laïka, S Haddouk, S Luce, JP Briand, L … - Diabetes, 2009 - Am Diabetes Assoc RESULTS— Five HLA-A2–restricted peptides were immunogenic in transgenic mice. Murine
T-cell clones specific for these peptides were cytotoxic against cells transfected with the preproinsulin
gene. They were recognized by peripheral blood mononuclear cells (PBMCs) from 17 of ... Cited by 2 - Related articles - All 4 versions
AK Moustakas, GK Papadopoulos - Current Pharmaceutical Design, 2009 - ingentaconnect.com Use of MHC II Structural Features in the Design of Vaccines for Organ- Specific Autoimmune
Diseases ... 1Department of Organic Farming, Educational Technological Institute of Ionian
Islands, GR27100 Argostoli, Cephallonia, GREECE; 2Laboratory of Biochemistry and ... Cited by 2 - Related articles
P Monti, AK Heninger, E Bonifacio - Current Diabetes Reports, 2009 - Springer Autoreactive T cells play a major role in the patho- genesis of type 1 diabetes mellitus
(T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing
or delaying the disease onset. However, the T-cell response against insulin- producing β ... Cited by 1 - Related articles - All 2 versions
E Martinuzzi, FA Lemonnier, C Boitard, R Mallone - System, 1927 - interscience.wiley.com Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease targeting pancreatic
β-cells. Despite this textbook definition, it is quite striking that neither the diagnosis nor the therapy
nor the follow-up of T1D "belong" to immunologists, but rather to endocrinologists whose ... Cited by 2 - Related articles - All 4 versions
BO Roep - DIABETES, 2008 - Am Diabetes Assoc W hile differentiating T-cell autoreactivity against pancreatic islets between type 1 diabetic patients
and nondiabetic control subjects has, over time, proven to be a difficult task, the ultimate challenge
for cellular markers of this disease will involve the definition of immunological measures ... Related articles
C Pfleger, G Meierhoff, H Kolb, NC Schloot - Journal of Autoimmunity, 2009 - Elsevier 50 adults and 49 children (mean age 27.3 and 10.9 years respectively) with recent onset type
1 diabetes who participated in a placebo-controlled trial of immune intervention with DiaPep277
were analyzed. Secretion of interferon (IFN)-γ, interleukin (IL)-5, IL-13 and IL-10 by single ... Related articles - All 2 versions
S Tsai, A Shameli, P Santamaria - Immunopathogenesis of Type 1 …, 2008 - books.google.com CD8+ T Cells in Type 1 Diabetes Sue Tsai, Afshin Shameli, and Pere Santamaria Contents
1. Introduction 80 2. MHC Class I and T1D 81 3. Autoreactive CD8+ T Cells in T1D 83 4. Antigens
for Diabetogenic CD8+ T Cells in Humans 86 4.1. GAD65 91 4.2. GFAP 91 4.3. IA-2 92 ... Cited by 1 - Related articles - All 2 versions
