M von Herrath, GT Nepom - Nature Immunology, 2009 - nature.com Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta
cells are damaged and destroyed. Animal models have served a prominent function in the development
of the present ideas of pathogenesis and approaches to therapy. This commentary ... Cited by 4 - Related articles - All 3 versions
JM Wenzlau, JC Hutton, HW Davidson - Current Opinion in …, 2008 - journals.lww.com Recent findings: Both type 1 diabetes and type 2 diabetes are associated with islet functional
failure and both diseases may be linked to stress responses and changes in the secretory
pathway, which lead to cell apoptosis and thus directly to reduction of β-cell mass or ... Cited by 2 - Related articles - All 3 versions
BA Wicklow, C Polychronakos - Expert Review of Clinical …, 2009 - ingentaconnect.com Mounting evidence suggests insulin is an important and potentially initiating antigen in the pathogenesis
of Type 1 diabetes. High-affinity insulin antibodies are found early in disease development and
appear to predict progression. Insulin is the only Type 1 diabetes auto-antigen with ... Related articles - All 3 versions
L Li, Q He, A Garland, Z Yi, LT Aybar, TB Kepler, … - The Journal of … - Am Assoc Immnol Page 1. of November 23, 2009 This information is current as doi:10.4049/jimmunol.0901587
published online Nov 16, 2009; J. Immunol. and Roland Tisch Aybar, Thomas B. Kepler, Jeffrey
A. Frelinger, Bo Wang Li Li, Qiuming He, Alaina Garland, Zuoan Yi, Lydia T. ...
- ►rupress.org C Louvet, BG Kabre, DW Davini, N Martinier, … - Journal of Experimental …, 2009 - jem.rupress.org Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously develop an autoimmune
peripheral neuropathy mediated by inflammatory CD4 + T cells that is reminiscent of
Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. To ... Related articles - All 4 versions
L Li, Q He, A Garland, Z Yi, LT Aybar, TB … - The Journal of …, 2009 - Am Assoc Immnol Type 1 diabetes is an autoimmune disease mediated by β cell-specific CD4 + and CD8 + T
cells. Tracking β cell-specific T cells is one approach to monitor the diabetogenic response in
at risk or diabetic individuals. Such analyses, however, are limited to PBL because T cells ...
M von Herrath, GT Nepom, B … - European Journal of …, 2009 - interscience.wiley.com Type 1 diabetes (T1D) occurs when the immune system attacks the insulin-producing beta cells
located in the islets of Langerhans within the pancreas. Animal models have played a prominent
role in developing an understanding of this disease process, through studies of genetic ... Related articles - All 2 versions
L Zhang, JM Jasinski, M Kobayashi, B Davenport, K … - Journal of Autoimmunity, 2009 - Elsevier Hybridomas with the complete BDC12-4.1 and BDC12-4.4 T cell receptors, despite having markedly
different TCR beta chains, responded to similar B:9-23 peptides. Approximately 1% of the hybridomas
from mice with the fixed TRAV5D-4*04 alpha chains and multiple endogenous beta ... Related articles - All 2 versions