- ►nih.gov A Nicolai, M Li, DH Kim, SJ Peterson, L Vanella, V … - Hypertension, 2009 - Am Heart Assoc Obesity-associated inflammation causes insulin resistance. Obese adipose tissue displays hypertrophied
adipocytes and increased expression of the cannabinoid-1 receptor. Cobalt protoporphyrin
(CoPP) increases heme oxygenase-1 (HO-1) activity, increasing adiponectin and ... Cited by 7 - Related articles - All 10 versions
- ►oxfordjournals.org J Axelsson - Nephrology Dialysis Transplantation, 2008 - ERA-EDTA Regardless of the implications, the incidence of obesity is increasing worldwide [1] and along
with it the proportion of the population subject to hypertension [1] or type-2 diabetes mellitus
[1]. Furthermore, the metabolic syndrome is an important risk factor for proteinuria and ... Cited by 3 - Related articles - All 9 versions
- ►nih.gov PL Hooper, PL Hooper - Cell Stress and Chaperones, 2009 - Springer Abstract We propose that type 2 diabetes results from a vicious cycle of metabolically induced
inflammation, im- paired insulin responsiveness, and subsequent loss of homeostatic
signaling. A crucial and previously under- recognized event contributing to this loss of ... Cited by 4 - Related articles - All 5 versions
JF Ndisang, N Lane, A Jadhav - American Journal of Physiology- …, 2009 - Am Physiological Soc In type 2 diabetes (T2D), postprandial and fasting hyperglycemia are important predictors of
cardiovascular diseases; however, few drugs are currently available to simultaneously suppress
these conditions. Here, we report an enduring antidiabetic effect of the heme oxygenase ( ... Cited by 4 - Related articles - All 4 versions
MP Soares, FH Bach - Trends in Molecular Medicine, 2009 - Elsevier Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that catabolizes free heme into carbon
monoxide, iron (which induces the expression of heavy-chain ferritin, an iron-sequestering
protein) and biliverdin (which is converted to bilirubin by biliverdin reductase). Over the ... Cited by 6 - Related articles - All 4 versions
JF Ndisang, A Jadhav - American Journal of Physiology- …, 2009 - Am Physiological Soc Hyperglycemia-induced oxidative stress is a common phenomenon in diabetes. Since oxidative
stress depletes adiponectin and insulin levels, we investigated whether an upregulated heme
oxygenase (HO) system would attenuate the oxidative destruction of adiponectin/insulin ... Cited by 4 - Related articles - All 3 versions
JF Ndisang, A Jadhav - Endocrinology, 2009 - Endocrine Soc Insulin-mediated signal transduction is positively correlated to adiponectin, adenosine
monophosphate-activated protein kinase (AMPK), and glucose-transporter-4 (GLUT4) but negatively
to oxidative/inflammatory mediators such as nuclear factor- B, activating-protein (AP)-1, ... Cited by 3 - Related articles - All 3 versions
Q Liu, L Sun, Y Tan, G Wang, X Lin, L … - Current medicinal …, 2009 - ingentaconnect.com 1 Departments of Medicine, Radiation Oncology, and Pharmacology and Toxicology, the University
of Louisville, Louis- ville, USA; 2 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional
Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and ... Cited by 2 - Related articles - All 3 versions
