B Komoroski, N Vachharajani, Y Feng, L Li, D … - Clinical Pharmacology & Therapeutics, 2009 - nature.com Dapagliflozin, administered to patients in once-daily oral doses, is a
sodium–glucose cotransporter 2 (SGLT2) inhibitor that blocks the reabsorption
of glucose from urine into the blood. This 14-day study randomized patients ... Cited by 11 - Related articles - All 4 versions
B Komoroski, N Vachharajani, D Boulton, D … - Clinical Pharmacology & Therapeutics, 2009 - nature.com Dapagliflozin selectively inhibits renal glucose reabsorption by inhibiting
sodium–glucose cotransporter-2 (SGLT2). It was developed as an
insulin-independent treatment approach for type 2 diabetes mellitus (T2DM). ... Cited by 6 - Related articles - All 4 versions
I Idris, R Donnelly - Diabetes Obes Metab, 2009 - interscience.wiley.com The sodium–glucose co-transporter-2 (SGLT2) is a low-affinity transport system
that is specifically expressed in the kidney and plays an important role in
renal glucose reabsorption in the proximal tubule. Competitive inhibition ... Cited by 5 - Related articles - All 3 versions
MA Abdul-Ghani, RA DeFronzo - Endocrine Practice, 2008 - AACE The prevalence of type 2 diabetes mellitus (T2DM) has increased progressively to
epidemic proportions dur- ing the past 20 years (1). Patients with T2DM have
increased morbidity and mortality, the majority of which results from ... Cited by 5 - Related articles - All 2 versions
GL Bakris, VA Fonseca, K Sharma, EM Wright - Kidney International, 2009 - nature.com The kidneys play a major role in the regulation of glucose in humans,
reabsorbing 99% of the plasma glucose that filters through the renal glomeruli
tubules. The glucose transporter, SGLT2, which is found primarily in the S1 ... Cited by 4 - Related articles - All 3 versions
M Kipnes - Expert Opinion on Investigational Drugs, 2009 - informahealthcare.com The global incidence of type 2 diabetes mellitus is increasing. Hyperglycemia
contributes to both the complications associated with diabetes mellitus and
progression of the underlying disease. New agents that lower blood glucose ... Cited by 1 - Related articles - All 6 versions
O Marsenic - American Journal of Kidney Diseases, 2009 - Elsevier The full significance of the kidney's role in glucose homeostasis is now well
recognized. For example, it is now known that renal gluconeogenesis contributes
substantially to total-body glucose release in the postabsorptive state. ... Cited by 1 - Related articles - All 2 versions
JR Colca - Expert Opin. Investig. Drugs, 2009 - informahealthcare.com There are many approaches being taken to try to improve the treatment options
for Type 2 diabetes. Over the past 10 years, there has been considerable effort
to find new insulin sensitizers based on the pharmacology demonstrated by ... Related articles - All 4 versions
S Nair, JPH Wilding - Journal of Clinical Endocrinology & Metabolism, 2009 - Endocrine Soc Context: Sodium-glucose cotransporter 2 (SGLT2) expressed in the proximal renal
tubules accounts for about 90% of the reabsorption of glucose from tubular
fluid. Genetic defects of SGLT2 result in a benign familial renal ...
SG Co-Transporters - dcpa.us Page 1. 1/6/2009 1 SODIUM GLUCOSE CO-TRANSPORTER 2 (SGLT2) INHIBITORS A
Novel Class of Antidiabetic Agents Lisa Brown, Pharm.D. PGY ... Related articles - View as HTML
