JD Cooper, DJ Smyth, AM Smiles, V Plagnol, … - Nature genetics, 2008 - pubmedcentral.nih.gov To provide more power to detect type 1 diabetes (T1D) loci, we performed a
meta-analysis of data from three genome-wide association (GWA) studies. We
tested 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ... Cited by 40 - Related articles - All 7 versions
JC Barrett, DG Clayton, P Concannon, B … - Nature Genetics, 2009 - nature.com Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the
action of multiple genetic and environmental risk factors. We report the
findings of a genome-wide association study of T1D, combined in a ... Cited by 28 - Related articles - All 3 versions
S Myles, D Davison, J Barrett, M Stoneking, … - BMC Medical Genomics, 2008 - biomedcentral.com On average, disease SNPs are not significantly more differentiated between
populations than random SNPs in the genome. Risk allele frequencies, however, do
show substantial variation across human populations and may contribute to ... Cited by 13 - Related articles - Cached - All 9 versions
LM Maier, CE Lowe, J Cooper, K Downes, DE … - PLoS Genetics, 2009 - pubmedcentral.nih.gov Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune
disorders with significant heritability, part of which is conferred by shared
alleles. For decades, the Human Leukocyte Antigen (HLA) complex was the ... Cited by 12 - Related articles - All 5 versions
SHS Pearce, TR Merriman - Endocrinology and Metabolism Clinics of North …, 2009 - Elsevier The search for the susceptibility alleles for the complex genetic conditions of
type 1 diabetes and autoimmune thyroid diseases has gained momentum in recent
years. Studies have revealed several novel disease susceptibility alleles ... Cited by 2 - Related articles - All 11 versions
WM Ridgway, LB Peterson, JA Todd, DB … - Advances in Immunology, 2008 - Elsevier Human genome wide association studies (GWAS) have recently identified at least
four new, non-MHC-linked candidate genes or gene regions causing type one
diabetes (T1D), highlighting the need for functional models to investigate ... Cited by 2 - Related articles - All 3 versions
J Araujo, L Segat, RL Guimarães, LAC … - Clinical Immunology, 2009 - Elsevier In our study we investigated the possible role of MBL2 functional single
nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other
autoimmune diseases in presence of type 1 diabetes (T1D) in a group of ... Cited by 1 - Related articles - All 2 versions
- ►nih.gov SM Raj, JMM Howson, NM Walker, JD Cooper, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis We used recently confirmed type 2 diabe- tes gene
regions to investigate the genetic relationship between type 1 and type 2
diabetes, in an average of 7,606 type 1 diabetic individuals and 8,218 ... Cited by 1 - Related articles - All 4 versions
DG Clayton, 2009 - pubmedcentral.nih.gov Much of the public media discussion of genetics of common diseases has centered
on opportunities for targeted preventive actions. At the same time, in the
specialist literature, there has been extensive discussion of ... Cited by 2 - Related articles - All 7 versions
H Källberg - diss.kib.ki.se "If you thought that science was certain - well, that is just an error on your
part." - Richard P Feynman "Science may set limits to knowledge, but should not
set limits to imagination." - Bertrand Russell Det krävs ett helt nytt ... Related articles
