JC Florez - Diabetologia, 2008 - Springer Abstract Although type 2 diabetes has been traditionally understood as a
metabolic disorder initiated by insulin resistance, it has recently become
apparent that an impairment in insulin secretion contributes to its mani- ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►geyseco.info [PDF] JC Florez - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Evidence Synthesis: As many as 17 genetic loci have been convincingly associated
with type 2 diabetes; 14 of these were not previously known, and most of them
were unsuspected. The associated polymorphisms are common in populations of ... Cited by 11 - Related articles - All 4 versions
- ►endojournals.org [PDF] JC Florez - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Page 1. THE GENETICS OF TYPE 2 DIABETES: A REALISTIC APPRAISAL CIRCA 2008 Short
title: The genetics of type 2 diabetes Jose C. Florez, MD, Ph.D. ... Cited by 3 - Related articles
Y Nakamura - Journal of human genetics, 2009 - nature.com DNA variations have contributed enormously to the fields of medical and forensic
science, especially through their use in studies on genes responsible or
susceptible to various diseases and those on screening of chromosomal ... Cited by 3 - Related articles - All 4 versions
- ►spendocrinologia.org.pe [PDF] H Staiger, F Machicao, A Fritsche, HU Haring - Endocrine Reviews, 2009 - Endocrine Soc Type 2 diabetes mellitus is a complex metabolic disease that is caused by
insulin resistance and β-cell dysfunction. Furthermore, type 2 diabetes has an
evident genetic component and represents a polygenic disease. During the ... Related articles - All 4 versions
J Huang, LL Levitsky, DB Rhoads - Experimental Cell Research, 2009 - Elsevier Hepatocyte nuclear factor 4α (HNF4α) is a critical transcription factor for
pancreas and liver development and functions in islet β cells to maintain
glucose homeostasis. Mutations in the human HNF4A gene lead to maturity ... Related articles - All 2 versions
KK Osbak, K Colclough, C Saint-Martin, NL … - Human Mutation, 2009 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a
crucial role in the regulation of insulin secretion and has been termed the
glucose sensor in pancreatic beta-cells. Given its central role in the ... Related articles - All 2 versions
KPL Ligaray, WL Isley - phx1.medscape.com Type 2 diabetes mellitus is a group of disorders characterized by hyperglycemia
and associated with microvascular (ie, retinal, renal, possibly neuropathic),
macrovascular (ie, coronary, peripheral vascular), and neuropathic (ie, ... Related articles - Cached - All 4 versions
