R Rong, RL Hanson, D Ortiz, C Wiedrich, S … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—FTO provided the strongest evidence for replication, where SNPs were
associated with type 2 diabetes (odds ratio = 1.20 per copy of the risk allele,
P = 0.03) and BMI (P = 0.002). None of the other previously reported SNPs ... Cited by 7 - Related articles - All 3 versions
PW Franks, KA Jablonski, LM Delahanty, JB … - Diabetologia, 2008 - Springer Page 1. ARTICLE Assessing gene–treatment interactions at the FTO and INSIG2 loci
on obesity-related traits in the Diabetes Prevention Program ... Cited by 5 - Related articles - All 4 versions
- ►endojournals.org AIF Blakemore, P Froguel - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Evidence Synthesis: The current genetic evidence in obesity underlines the
importance of neuroendocrine mechanisms of appetite regulation. Monogenic forms
of disease explain 6% of children with extreme obesity, having hyperphagia ... Cited by 6 - Related articles - All 3 versions
R Lennon, D Pons, MA Sabin, C Wei, JP … - Nephrology Dialysis Transplantation, 2009 - ERA-EDTA Background. Cellular insulin resistance is the hallmark of type 2 diabetes and
predominantly affects adipose and muscle cells. The saturated free fatty acid
palmitate is elevated in insulin-resistant states and may directly ... Cited by 2 - Related articles - All 3 versions
CIG Vogel, B Greene, A Scherag, TD Müller, S … - BMC Medical Genetics, 2009 - biomedcentral.com A recent genome-wide association (GWA) study of US Caucasians suggested that
eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with
obesity and increased fat mass. We analysed the respective SNPs in data ... Cited by 2 - Related articles - Cached - All 5 versions
IM Heid, C Huth, RJF Loos, F Kronenberg, V … - PLoS Genet, 2009 - plosgenetics.org A polymorphism of the INSIG2 gene was identified as being associated with
obesity in one of the first genome-wide association studies. However, this
association has since then been highly debated upon inconsistent subsequent ... Related articles - Cached - All 3 versions
SW van den Berg, MET Dollé, S Imholz… - International Journal of Obesity, 2009 - nature.com As nuclear receptors and transcription factors have an important regulatory
function in adipocyte differentiation and fat storage, genetic variation in
these key regulators and downstream pathways may be involved in the onset ... Related articles - All 3 versions
- ►spendocrinologia.org.pe [PDF] H Staiger, F Machicao, A Fritsche, HU Haring - Endocrine Reviews, 2009 - Endocrine Soc Type 2 diabetes mellitus is a complex metabolic disease that is caused by
insulin resistance and β-cell dysfunction. Furthermore, type 2 diabetes has an
evident genetic component and represents a polygenic disease. During the ... Related articles - All 4 versions
JV van Vliet-Ostaptchouk, MH Hofker, YT … - Obesity Reviews, 2009 - interscience.wiley.com We summarize current knowledge on the physiological role of the hypothalamus in
body-weight regulation and review genetic studies on the hypothalamic candidate
genes in relation to obesity. Together, data from functional and genetic ... Related articles
S Cha, I Koo, BL Park, S Jeong, SM Choi, KS … - Evidence-based Complementary and Alternative …, 2009 - Oxford Univ Press Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes
human beings into four types through states of physiological imbalances and
responsiveness to herbal medicine. One SCM type susceptible to obesity ... Related articles - All 3 versions