H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed predominantly in pancreatic
islets mediating free fatty acid–induced insulin secretion. However, the physiological role of FFAR1
remains controversial. It was previously reported that FFAR1 knockout (Ffar1 −/− ) mice ... Cited by 9 - Related articles - All 5 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable
interest in their pharmacology and function because of the wide range of normal physiology and
disease states in which fatty acids have been implicated. Free fatty acid receptor (FFA) 1 ... Cited by 9 - Related articles - All 5 versions
G Tolhurst, F Reimann, FM Gribble - The Journal of Physiology, 2009 - Physiological Soc Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important
role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic
successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its ... Cited by 8 - Related articles - All 5 versions
Y Fujita, RD Wideman, M Speck, A Asadi, … - American Journal of …, 2009 - Am Physiological Soc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are
released during meals from endocrine cells located in the gut mucosa and stimulate insulin secretion
from pancreatic β-cells in a glucose-dependent manner. Although the gut epithelium ... Cited by 5 - Related articles - All 3 versions
CW Liaw, DT Connolly - DNA and Cell Biology, 2009 - liebertonline.com GPR41 and GPR42 are two closely related genes that are part of a cluster of four adjacent G
protein-coupled receptors (GPCRs) (GPR40, 41, 42, and 43) localized on human chromosome
19. There are only six nucleotide and amino acid differences between GPR41 and ... Cited by 1 - Related articles - All 3 versions
- ►pbrc.edu [PDF] P Wellendorph, LD Johansen, H Brauner-Osborne - Molecular Pharmacology, 2009 - ASPET A number of highly promiscuous seven transmembrane (7TM) receptors have been cloned and
characterized within the last few years. It is noteworthy that many of these receptors are activated
broadly by amino acids, proteolytic degradation products, carbohydrates, or free fatty ... Cited by 1 - Related articles - All 5 versions
A Ichimura, A Hirasawa, T Hara, G Tsujimoto - Prostaglandins and Other Lipid …, 2009 - Elsevier Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled
receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). These fatty acid receptors
are proposed to play critical roles in a variety of types of physiological homeostasis. ... Related articles - All 2 versions
MA Kebede, T Alquier, MG Latour, V Poitout - Diabetes, Obesity and …, 2009 - poitoutlab.ca G-protein coupled receptors (GPCRs) are targets of approximately 30% of currently marketed
drugs. Over the last few years, a number of GPCRs expressed in pancreatic β-cells and activated
by lipids have been discovered. GPR40 was shown to be activated by medium- to long- ... Related articles - View as HTML - All 3 versions
RD Wideman, TJ Kieffer - Trends in Endocrinology & Metabolism, 2009 - Elsevier The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like
peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple
blood glucose-lowering effects. Recent years have seen a surge of interest in ... Related articles - All 3 versions
