P Fiorina, AMJ Shapiro, C Ricordi, A Secchi, A … - Am J Transplant, 2008 - sorgente-salute.it Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches
to im- proving glycometabolic control in diabetic patients and, in many cases, achieving insulin
independence. Unfortunately, many persistent flaws still prevent islet transplantation from ... Cited by 14 - Related articles - View as HTML - All 11 versions
T Weichhart, MD Säemann - Trends in Immunology, 2009 - Elsevier The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine–threonine
kinase that is known to sense the environmental and cellular nutrition status to control cell
growth. In immunity, mTOR is essential for both the proper activation and subsequent ... Cited by 5 - Related articles - All 2 versions
O Bestard, JM Cruzado, JM Grinyó - Transplantation, 2009 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 1 - Related articles - All 2 versions
G Jiang, Y Cui, X Zhong, S Tai, W Liu, Z Wang, Y … - Archives of medical …, 2009 - Elsevier Type 1 diabetes (T1D) is an autoimmune disorder that results in destruction of insulin-releasing
β-cells of the pancreas. During the pathogenesis of T1D, at least two phases of β-cell death
occur: an initiation event wherein macrophage-derived inflammatory cytokines induce ... Related articles - All 8 versions
SA De Serres, MH Sayegh, N Najafian - Clinical Journal of the …, 2009 - Am Soc Nephrol To define therapeutic strategies that promote tolerance, it is of critical importance to determine
the effects of immunosup- pressive drugs on regulatory T cells (Tregs). This review discusses
the current knowledge about the physiology of Tregs in humans, the role or Tregs in ... Related articles - All 3 versions
[CITATION] The authors review islet transplant outcomes and immunosuppression, and in …
P Fiorina, AMJ Shapiro, C Ricordi, A … - American Journal of …, 2008 - Blackwell Publishing Inc Related articles
J Yuen-Shan Tsang, Y Tanriver, S Jiang, E Leung, K … - Transplant Immunology, 2009 - Elsevier CD4 + CD25 + regulatory T cells (Tregs) play a crucial role in controlling immune responses.
It is an appealing strategy to harness Tregs for adoptive cell therapy to induce tolerance to
allografts. Several approaches have been developed to expand antigen-specific Tregs. ... Related articles - All 2 versions
M Donia, K Mangano, A Amoroso, MC Mazzarino, R … - Journal of Autoimmunity, 2009 - Elsevier We have presently evaluated the effects of the immunomodulatory drug rapamycin on the course
of protracted relapsing experimental allergic encephalomyelitis (PR-EAE) in Dark Agouti
(DA) rats, which serves as a preclinical model of multiple sclerosis. The data show that ... Related articles - All 2 versions
N Gagliani, A Ferraro, MG Roncarolo, M Battaglia - Immunology Letters, 2009 - Elsevier Regulatory T cells (Tregs) are thought to be pivotal in controlling both autoimmune and allogeneic
undesired immune responses. Recently, an extensive effort has been devoted to design clinical
trials with Tregs in T cell-mediated diseases (such as autoimmune diseases or ... Related articles - All 2 versions