H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed
predominantly in pancreatic islets mediating free fatty acid–induced insulin
secretion. However, the physiological role of FFAR1 remains controversial. ... Cited by 9 - Related articles - All 5 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty
acids has led to considerable interest in their pharmacology and function
because of the wide range of normal physiology and disease states in which ... Cited by 9 - Related articles - All 5 versions
V Poitout, J Amyot, M Semache, B Zarrouki, D … - BBA-Molecular and Cell Biology of Lipids, 2009 - Elsevier The concept of glucolipotoxicity refers to the combined, deleterious effects of
elevated glucose, and fatty acid levels on pancreatic beta-cell function and
survival. Significant progress has been made in recent years towards a ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►cell.com CJ Nolan, M Prentki - Trends in Endocrinology & Metabolism, 2008 - Elsevier The pancreatic β-cell senses blood nutrient levels and is modulated by
neurohormonal signals so that it secretes insulin according to the need of the
organism. Nutrient sensing involves marked metabolic activation, resulting ... Cited by 7 - Related articles - All 8 versions
R Brownlie, R Mayers, J Pierce, A Marley, D … - Biochemical Society Transactions, 2008 - biochemsoctrans.org GPR40 (G-protein-coupled receptor 40) has been shown to be a physiologically
relevant receptor for long-chain fatty acids. It is a family A G-protein-coupled
receptor highly expressed in the β-cell where it increases insulin ... Cited by 5 - Related articles - Cached - All 4 versions
NJ Smith, LA Stoddart, NM Devine, L Jenkins, … - Journal of Biological Chemistry, 2009 - ASBMB The endogenous ligands for free fatty acid receptor 1 (FFA1) are medium and
longer chain free fatty acids. However, a range of selective, small molecule
ligands have recently been developed as tool compounds to explore the ... Cited by 1 - Related articles - All 4 versions
MA Kebede, T Alquier, MG Latour, V Poitout - Diabetes, Obesity and Metabolism, 2009 - poitoutlab.ca G-protein coupled receptors (GPCRs) are targets of approximately 30% of
currently marketed drugs. Over the last few years, a number of GPCRs expressed
in pancreatic β-cells and activated by lipids have been discovered. GPR40 ... Related articles - View as HTML - All 3 versions
EK Vassiliou, A Gonzalez, C Garcia, JH … - Lipids in Health and Disease, 2009 - biomedcentral.com Address: 1Department of Biological Sciences, Kean University, 1000 Morris
Avenue, Union, New Jersey 07083, USA, 2Department of Medicine, St. Joseph's
Hospital, 703 Main Street, Paterson, New Jersey 07503, USA, 3Department of ... Related articles - View as HTML - All 11 versions
SB Bharate, KVS Nemmani, RA Vishwakarma - Expert Opin. Ther. Patents, 2009 - informahealthcare.com Background: The family of G-protein-coupled receptors (GPCRs) serves as the
target for almost a third of currently marketed drugs and provides the
predominant mechanism through which extracellular factors transmit signals ... Related articles - All 5 versions
- ►ubc.ca [PDF] KS Gwiazda - dspace.library.ubc.ca Page 1. ROLE OF ENDOPLASMIC RETICULUM CALCIUM STORES IN BETA-CELL ER STRESS
AND LIPOTOXICITY by KAMILA SABINA GWIAZDA B.Sc., The ... Related articles - View as HTML - All 2 versions
