- ►posterous.com [PDF] JR Greenfield, JW Miller, JM Keogh, E … - New England Journal …, 2009 - content.nejm.org Results The prevalence of hypertension was markedly lower in the MC4R-deficient subjects
than in the control subjects (24% vs. 53%, P=0.009). After the exclusion of subjects taking antihypertensive
medications, blood-pressure levels were significantly lower in MC4R-deficient subjects ... Cited by 19 - Related articles - All 6 versions
- ►endojournals.org AIF Blakemore, P Froguel - Journal of Clinical Endocrinology & …, 2008 - Endocrine Soc Evidence Synthesis: The current genetic evidence in obesity underlines the importance of neuroendocrine
mechanisms of appetite regulation. Monogenic forms of disease explain 6% of children with
extreme obesity, having hyperphagia associated with defects in the leptin-melanocortin ... Cited by 6 - Related articles - All 3 versions
K Tan, ID Pogozheva, GSH Yeo, D Hadaschik, JM … - Endocrinology, 2009 - Endocrine Soc Mutations in the melanocortin 4 receptor (MC4R) gene are the most common known cause of
monogenic human obesity. The MC4R gene was sequenced in 2000 subjects with severe
early-onset obesity. We detected seven different nonsense and 19 nonsynonymous ... Cited by 4 - Related articles - All 4 versions
CL Roth, M Ludwig, J Woelfle, ZC Fan, H Brumm, H … - Endocrine, 2009 - Springer Abstract This study targeted the identification of muta- tions of melanocortin-4 receptor gene
(MC4R) in obese children. Fifty-one unrelated probands with early onset severe obesity (body
mass index (BMI) [99th percentile; 21 girls, mean age 10.6 ± 3.6 years) were analyzed for ... Cited by 3 - Related articles - All 2 versions
J Yan - etd.auburn.edu Except where the reference is made to the work of others, the work described in this thesis is
my own or was done in collaboration with my advisory committee. This thesis does not include
proprietary or classified information. ... Anatomy, Physiology & Pharmacology Anatomy, ... Related articles - View as HTML
YX Tao - G Protein-Coupled Receptors in Health and Disease, 2009 - books.google.com Mutations in Melanocortin‐4 Receptor and Human Obesity Ya‐Xiong Tao Department of
Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn
University, Auburn, Alabama 36849 I. Introduction......................................................................... ... Related articles
N Santoro, G Cirillo, Z Xiang, R Tanas, N … - BMC Medical …, 2009 - biomedcentral.com Melanocortin-4-receptor (MC4R) mutations represent the most frequent genetic cause of
non-syndromic early onset obesity. Children carrying MC4R mutations seem to show a particular
phenotype characterized by early onset, severe obesity and high stature. To verify ... Related articles - Cached - All 5 versions
JV van Vliet-Ostaptchouk, MH Hofker, YT van … - Obesity …, 2009 - interscience.wiley.com We summarize current knowledge on the physiological role of the hypothalamus in body-weight
regulation and review genetic studies on the hypothalamic candidate genes in relation to
obesity. Together, data from functional and genetic studies as well as the new, common, ... Related articles
AJ Stunkard - TITLE: Circadian Biology and Sleep: Missing Links in … - dtic.mil A Biobehavioral Model of the Night Eating Syndrome Albert J. Stunkard, MD University of
Pennsylvania, Pittsburgh, PA The Night Eating Syndrome is an eating disorder consisting of
evening hyperphagia (at least 25% of daily caloric intake after supper) and/or two ... Related articles - View as HTML - All 4 versions
R Hardy, AK Wills, A Wong, CE Elks, NJ … - Human Molecular …, 2009 - Oxford Univ Press The timing of associations between common genetic variants for weight or body mass index
(BMI) across the life course may provide insights into the aetiology of obesity. We genotyped
variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 ...